Arenaria serpyllifolia as a natural antiviolaceum agent: Phytochemical, biological, and molecular approaches

Basit Öğe Kaydı
dc.contributor.authorKülahcı, Meryem Burcu
dc.contributor.authorAydın, Betül
dc.contributor.authorİncilay Torunoğlu, Emine
dc.contributor.authorDüzgün, Zekeriya
dc.contributor.authorDurmaz, Alper
dc.contributor.authorAytar, Erdi Can
dc.date.accessioned2025-10-01T10:53:50Z
dc.date.available2025-10-01T10:53:50Z
dc.date.issued2025
dc.departmentAÇÜ
dc.description.abstractThis study investigates the antioxidant, antimicrobial, antibiofilm, and antiquorum sensing activities of Arenaria serpyllifolia extract. A methanolic extract from the plant's above-ground parts is prepared via maceration. The extract exhibits strong antioxidant properties (DPPH IC50: 355.54 ± 20.62 μg mL−1) and iron chelating ability (IC50: 5.30 ± 4.44 mg mL−1). Total flavonoid and phenolic contents are 75.15 ± 2.73 mg quercetin equivalent g−1 and 150.83 ± 11.24 mg gallic acid equivalent g−1, respectively. Antimicrobial tests show notable activity against Chromobacterium violaceum (minimal inhibitory concentration (MIC) < 5 mg mL−1). Antibiofilm effects are significant with 82.52% and 81.32% inhibition at MIC and sub-MIC levels. The extract also inhibits violacein production in the C. violaceum CV12472 strain (90.76% at MIC). Gas chromatography-mass spectrometry analysis identifies seven major compounds, including allyl isothiocyanate and levoglucosan. Molecular docking reveals levoglucosan as the most potent CviR receptor binder (−6.8 kcal mol−1). These interactions suggest possible quorum sensing inhibition via antagonism. Molecular dynamics simulations confirm the stability of the ligand–receptor complexes, highlighting guanosine and levoglucosan as promising leads for drug development.
dc.identifier.doi10.1002/open.202500236
dc.identifier.issn21911363
dc.identifier.pmid40662310
dc.identifier.scopus2-s2.0-105010655124
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/11494/5935
dc.identifier.wosWOS:001529013700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorDurmaz, Alper
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofChemistryOpen
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntibiofilm activity
dc.subjectAntimicrobial activity
dc.subjectAntioxidant activity
dc.subjectAntiquorum sensing
dc.subjectArenaria serpyllifolia
dc.subjectMolecular docking
dc.subjectMolecular dynamics simulations
dc.titleArenaria serpyllifolia as a natural antiviolaceum agent: Phytochemical, biological, and molecular approaches
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
5935.pdf
Boyut:
1.38 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Ali Nihat Gökyiğit Botanik Bahçesi Uygulama ve Araştırma Merkezi
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu