Astaxanthin alleviates renal damage of rats on high fructose diet through modulating NF kappa B/SIRT1 pathway and mitigating oxidative stress

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dc.contributor.authorİskender, Hatice
dc.contributor.authorYenice, Güler
dc.contributor.authorDokumacıoğlu, Eda
dc.contributor.authorHayırlı, Armağan
dc.contributor.authorSevim, Çiğdem
dc.contributor.authorDokumacıoğlu, Ali
dc.contributor.authorKapakın, Kübra Asena Terim
dc.date.accessioned2020-02-13T07:04:21Z
dc.date.available2020-02-13T07:04:21Z
dc.date.issued2020
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.descriptionCoordinator of Scientific Research Projects at Artvin Coruh University: 2016.M80.02.08en_US
dc.description.abstractThis study was conducted to determine the effect of astaxanthin (ASX) treatment on alleviation ofrenal damage in high fructose induced nephrotoxicity in rats. Treatments were arranged in a 2 2 fac-torial fashion: administrations of fructose (30%, via drinking water) and ASX (1 mg/kg/day, within0.2ml olive oil) for 8 weeks. Data were analyzed by two-way ANOVA. The ASX treatment decreasedserum urea (p<.01) and blood urea–N concentrations (p<.02) at a lower extent in rats receiving fruc-tose than those not receiving fructose. Moreover, the ASX treatment reversed the increases in malon-dialdehyde (MDA) (p<.0001) and nuclear factor kappa B (NF-jB) (p<.0003) levels and the decreasesin superoxide dismutase (SOD) activity (p<.0001) and sirtuin-1 (SIRT1) level (p<.0004), in the kidneyupon high fructose consumption. The data suggest that ASX supplementation alleviates renal damageinduced by high fructose consumption through modulating NF-jB/SIRT1 pathway and mitigating oxi-dative stress.
dc.identifier.citationIskender, H., Dokumacioglu, E., Yenice, G., Hayirli, A., Sevim, C., Dokumacioglu, A., & Terim Kapakin, K. A.. (2020). Astaxanthin alleviates renal damage of rats on high fructose diet through modulating NFκB/SIRT1 pathway and mitigating oxidative stress. Archives of Physiology and Biochemistry. 126(1), 89-93. https://doi.org/10.1080/13813455.2018.1493609en_US
dc.identifier.doi10.1080/13813455.2018.1493609
dc.identifier.endpage93en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage89en_US
dc.identifier.urihttps://hdl.handle.net/11494/1971
dc.identifier.volume126en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDokumacıoğlu, Eda
dc.institutionauthorİskender, Hatice
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofArchives of Physiology and Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFructoseen_US
dc.subjectNF-jBen_US
dc.subjectOxidativestressen_US
dc.subjectSIRTen_US
dc.subjectAstaxanthinen_US
dc.titleAstaxanthin alleviates renal damage of rats on high fructose diet through modulating NF kappa B/SIRT1 pathway and mitigating oxidative stressen_US
dc.typeArticle

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