High-fructose in drinking water initiates activation of inflammatory cytokines and testicular degeneration in rat

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dc.authorid0000-0002-6422-1203en_US
dc.authorid0000-0002-6422-1203en_US
dc.contributor.authorYıldırım, Onur Gökhan
dc.contributor.authorSumlu, Esra
dc.contributor.authorAslan, Esra
dc.contributor.authorKoca, Halit Buğra
dc.contributor.authorPektaş, Mehmet Bilgehan
dc.contributor.authorSadi, Gökhan
dc.contributor.authorAkar, Fatma
dc.date.accessioned2020-11-04T07:29:45Z
dc.date.available2020-11-04T07:29:45Z
dc.date.issued2019
dc.departmentAÇÜ, Sağlık Hizmetlerien_US
dc.description.abstractThe increased consumption of high-fructose in diet may contribute to high prevalence of metabolicsyndrome in the world. The influence of high-fructose diet on male reproductive system has beenpoorly documented. In this study, we investigated the effects of dietary high-fructose on the expres-sion of inflammatory cytokines in association with certain testicular proteins and sex hormones in thetestis of rats. Fructose was given to the rats as 20% solution (7.8 mg/kg) in drinking water for15 weeks. Dietary high-fructose caused testicular degeneration, also decreased testicular concentrationof testosterone and right testis absolute weight. This dietary intervention increasediNOSandTNF-amRNAs as well as iNOS, NF-jB, and p-NF-jbproteins, but decreasedIL-10andIL-6mRNAs expressions,in testicular samples of rats. Moreover, testicular TNF-a, IL-1b, and iNOS and plasma IL-1blevels weresignificantly increased in rats fed with fructose. A marked increase in the expression level of IGF-1Rprotein was considered in testicular tissue of fructose-treated rats. The expression intensities of c-kit,claudin-1, and pan-cadherin were comparable in seminiferous tubules of control and fructose-treatedrats. In conclusion, high-fructose intake of rats leads to activation of inflammatory cytokines, which isaccompanied by testicular degeneration. These changes could be responsible for hormonal dysfunc-tion with low intra-testicular testosterone level, which could be relevant to male infertility.
dc.description.sponsorshipGazi University: BAP 02/2017-20en_US
dc.identifier.citationYıldırım, O. G., Sumlu, E., Aslan, E., Koca, H. B., Pektaş, M. B., Sadi, G., & Akar, F. (2019). High-fructose in drinking water initiates activation of inflammatory cytokines and testicular degeneration in rat. Toxicology mechanisms and methods, 29(3), 224-232. Doi: 10.1080/15376516.2018.1543745en_US
dc.identifier.doi10.1080/15376516.2018.1543745
dc.identifier.endpage232en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage224en_US
dc.identifier.urihttps://hdl.handle.net/11494/2408
dc.identifier.volume29en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYıldırım, Onur Gökhan
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofToxicology Mechanisms and Methods
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectiNOS: inducible nitric oxide synthaseen_US
dc.subjectIL: interleukinen_US
dc.subjectNF-jB: nuclear factor-kappa Ben_US
dc.subjectTNF-a: tumor necrosis factor-alphaen_US
dc.subjectIGF-1R: type I insulin-like growth factor receptoren_US
dc.titleHigh-fructose in drinking water initiates activation of inflammatory cytokines and testicular degeneration in raten_US
dc.typeArticle

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