Investigation of relationship between IL-6 gene variants and hypertension in Turkish population

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dc.authorid0000-0001-8567-807Xen_US
dc.authorid0000-0003-0783-6014en_US
dc.authorid0000-0002-7261-6790en_US
dc.contributor.authorKaraman, Esin
dc.contributor.authorKüçük, Meral Urhan
dc.contributor.authorBayramoğlu, Ayşegül
dc.contributor.authorGöçmen, Semire Uzun
dc.contributor.authorErcan, Süleyman
dc.contributor.authorGüler, Halil İbrahim
dc.contributor.authorKüçükkaya, Yunus
dc.contributor.authorErden, Sema
dc.date.accessioned2020-11-12T08:33:19Z
dc.date.available2020-11-12T08:33:19Z
dc.date.issued2015
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.description.abstractHypertension (HT) is a common and life threating health problem worldwide leading to stroke, heart attack and renal failure. It is characterized by elevated blood pressure forced heart load. Human interleukin-6 (IL-6) and C- reactive protein (CRP) are known to be involved in inflammatory processes. IL-6 gene is a polymorphic gene which -174 G/C is a common and -572 G/C is a rare polymorphisms identified in promoter region. Publications on IL-6 gene polymorphisms raised the question whether this gene polymorphisms lead to susceptibility to HT or not. To investigate the effects of IL-6 gene -174 G/C (rs 1800795) and -572 G/C (rs1800796) polymorphisms on plasma IL-6 and CRP levels and their associations with hypertension disease in Turkish population we analyzed -174 G/C and -572 G/C polymorphisms and plasma IL-6 and CRP levels in 111 healthy controls and 108 hypertension patients from Adyaman, Turkey. We determined the genotypes using polymerase chain reaction-restriction fragment length polymorphism and analyzed plasma levels of IL-6 by ELISA and CRP by automated standard biochemical methods. We have found no statistically significant differences between IL-6 gene -174 G/C and -572 G/C genotypes and allelic frequencies and IL-6 and CRP plasma levels and HT (p > 0.05). No CC genotype was found in control subjects for -572 G/C polymorphism. In conclusion, we found relation to -174 G/C and -572 G/C gene variants between neither IL-6 and CRP levels nor hypertension. The -572 G allele and GG genotype are predominant in Turkish population in Adyaman, Turkey whereas the CC genotype is very rare.
dc.description.sponsorshipThis study was supported by a grant of the Research Foundation of Adiyaman University (FEFYL/2012-0002), Turkey.en_US
dc.identifier.citationKaraman, E., Küçük, M. U., Bayramoğlu, A., Göçmen, S. U., Ercan, S., Güler, H. I., ... & Erden, S. (2015). Investigation of relationship between IL-6 gene variants and hypertension in Turkish population. Cytotechnology, 67(6), 947-954.en_US
dc.identifier.doi10.1007/s10616-014-9732-1
dc.identifier.endpage954en_US
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage947en_US
dc.identifier.urihttps://hdl.handle.net/11494/2444
dc.identifier.volume67en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBayramoğlu, Ayşegül
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCytotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHypertensionen_US
dc.subjectIL-6 gene polymorphismen_US
dc.subject-174 G/Cen_US
dc.subject-572 G/C gene variantsen_US
dc.subjectCRPen_US
dc.titleInvestigation of relationship between IL-6 gene variants and hypertension in Turkish populationen_US
dc.typeArticle

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