Effects of astaxanthin on biochemical and histopathological parameters related to oxidative stress on testes of rats on high fructose regime

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dc.contributor.authorDokumacıoğlu, Eda
dc.contributor.authorİskender, Hatice
dc.contributor.authorYenice, Güler
dc.contributor.authorTerim Kapakin, Kuebra Asena
dc.contributor.authorÇiğdem, Sevim
dc.contributor.authorHayırlı, Armağan
dc.contributor.authorSaral, Sinan
dc.contributor.authorÇomaklı, Selim
dc.date.accessioned2020-02-07T09:56:32Z
dc.date.available2020-02-07T09:56:32Z
dc.date.issued2018
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.description.abstractAstaxanthin (ASX) is a xanthophyll family of hydroxycarotenoids which contains sev-eral double bonds. It is produced by Haemococcus pluvialis, a microalgae and pos-sesses antioxidant and anti-inflammatory properties. The aim of this study was to test whether ASX could protect against oxidative damage in the testicular tissues of rats receiving high fructose. The rats (n = 24) were randomly divided into two main groups: control and fructose (30%, via drinking water) and then each main group ei-ther not supplemented or supplemented with ASX (1 mg kg?1 day?1, within 0.2 ml olive oil) via oral gavage. Data were subjected to two-way ANOVA. High fructose consumption tended to increase testis weight and serum testosterone concentration and decreased testicular tissue glutathione-S- transferase (GST) and superoxide dis-mutase (SOD) levels, but did not affect testicular tissue malondialdehyde (MDA) con-centration. Astaxanthin administration increased testosterone, GST and SOD levels and testis weight and decreased MDA concentration. However, ASX administration did not reverse alterations in antioxidant parameters caused by high fructose con-sumption. Inducible nitric oxide synthase (iNOS) tended to increase in sertoli cell, spermatid and spermatogonia, but not in spermatocytes and leydig cell in response to high fructose consumption. Astaxanthin administration tended to reverse elevation in iNOS in testis cells. In conclusion, ASX could help alleviate oxidative damage caused by high fructose consumption
dc.identifier.citationDokumacioglu, E., Iskender, H., Yenice, G., Kapakin, K. A. T., Sevim, C., Hayirli, A., ... & Comakli, S. (2018). Effects of astaxanthin on biochemical and histopathological parameters related to oxidative stress on testes of rats on high fructose regime. Andrologia, 50(7), e13042.DOI: 10.1111/and.13042en_US
dc.identifier.doi10.1111/and.13042
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/11494/1957
dc.identifier.volume50en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorİskender, Hatice
dc.institutionauthorDokumacıoğlu, Eda
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAstaxanthinen_US
dc.subjectFructoseen_US
dc.subjectOxidative stressen_US
dc.subjectTestesen_US
dc.titleEffects of astaxanthin on biochemical and histopathological parameters related to oxidative stress on testes of rats on high fructose regimeen_US
dc.typeArticle

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