Dietary high-fructose reduces barrier proteins and activates mitogenic signalling in the testis of a rat model: Regulatory effects of kefir supplementation

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dc.authorid0000-0003-0090-7369en_US
dc.contributor.authorAkar, Fatma
dc.contributor.authorYıldırım, Onur Gökhan
dc.contributor.authorYücel Tenekeci, Gözde
dc.contributor.authorTunç, Arda Selin
dc.contributor.authorDemirel, Murşide Ayşe
dc.contributor.authorSadi, Gökhan
dc.date.accessioned2021-12-17T06:23:10Z
dc.date.available2021-12-17T06:23:10Z
dc.date.issued2021
dc.departmentAÇÜ, Sağlık Hizmetleri Meslek Yüksekokulu, Eczane Hizmetleri Bölümüen_US
dc.description.abstracthere are limited data on the influence of fructose rich diet on the male reproductive system. Kefir may have health beneficial effects, but its mechanism of action remains mostly unclear. Herein, we investigated the impact of dietary high fructose on tight junction proteins and mitogenic pathways in rat testis as well as their modulation by kefir supplementation. Twenty-two male Wistar rats (4 weeks old) were divided into the following three groups: Control; Fructose; Fructose + Kefir. Fructose was added to drinking water at concentration of 20% and administered to the rats for 15 weeks and kefir was supplemented by gavage once a day during final 6 weeks. Dietary fructose-induced testicular degeneration was associated with the downregulation of the blood–testis barrier proteins, claudin-11 and N-cadherin as well as SIRT1 expression in testicular tissue of rats. However, p38MAPK, p-p38MAPK and p-ERK1/2 levels were increased in testis of fructose-fed rats. Interestingly, JNK1 and p-JNK1 protein levels were decreased following this dietary intervention. Raf1, ERK1/2, and caspase 3 and TUNEL staining of the testis reveal the activation of apoptosis due to fructose intake. Kefir supplementation markedly promoted the expression of claudin-11, SIRT1, JNK1 and p-JNK1 but suppressed testicular mitogenic and apoptotic factors in fructose-fed rats.
dc.identifier.citationAkar, F., Yıldırım, O. G., Yücel Tenekeci, G., Tunc, A. S., Demirel, M. A., & Sadi, G. (2021). Dietary high‐fructose reduces barrier proteins and activates mitogenic signalling in the testis of a rat model: Regulatory effects of kefir supplementation. Andrologia, e14342.en_US
dc.identifier.doi10.1111/and.14342
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/11494/3610
dc.identifier.volumeArticle in pressen_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYıldırım, Onur Gökhan
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBarrier proteinsen_US
dc.subjectDietary fructoseen_US
dc.subjectKefiren_US
dc.subjectMAPK/ERK pathwayen_US
dc.subjectTestisen_US
dc.titleDietary high-fructose reduces barrier proteins and activates mitogenic signalling in the testis of a rat model: Regulatory effects of kefir supplementationen_US
dc.typeArticle

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