Effect of hesperidin treatment on α-Klotho/FGF-23 pathway in rats with experimentally-induced diabetes

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dc.authorid0000-0002-2223-1331en_US
dc.contributor.authorDokumacıoğlu, Eda
dc.contributor.authorİskender, Hatice
dc.contributor.authorMusmul, Ahmet
dc.date.accessioned2020-11-03T06:19:31Z
dc.date.available2020-11-03T06:19:31Z
dc.date.issued2019
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.description.abstractObjective Non-alcoholic fatty liver disease, steatohepatitis and nephropathy are considered among the mostimportant complications of diabetes mellitus (DM), which recently increased due to increased frequency of DMand the prolonged life span of diabetic patients The aim of the present study was to reveal the possible effect ofhesperidin (HP) on alpha-klotho (?-KL)/fibroblast growth factor-23 (FGF-23) pathway in rats with diabetesinduced by streptozotocin (STZ).Materials and methods Thirty six male Sprague-Dawley rats were randomly divided into three groups. Therats of the control, diabetes, and treatment groups were fed with standard feed and water throughout the 2-weekstudy. In order to induce diabetes mellitus in rats, those in the diabetes group were administered a single dose of50 mg/kg STZ. For the DM + HP group, a single dose of 50 mg/kg STZ, when diabetes was induced, hesperidinwas administered orally at a dose of 100 mg/kg by gavage.Results The?-KL levels of our study groups, both the liver and kidney?-KL levels and serum?-KL of the STZ-induced diabetic group were statistically significantly lower than the control group (respectively, p < 0.05,p < 0.001, p < 0.05). It was observed that hesperidin administration statistically significantly increased?-KLlevels in serum, liver and renal tissue (p < 0.001). Liver, kidney and serum FGF-23 levels of the diabetic groupincreased significantly in comparison to the control group (respectively, p < 0.05, p < 0.01, p < 0.001). FGF-23 levels that increased in kidney tissue and serum samples of the diabetic group decreased statistically sig-nificantly with hesperidin administration (respectively, p < 0.01, p < 0.001).Conclusion The?-KL/FGF-23 pathway is a promising bio-indicator in various cases of systemic toxicity andpathology. In addition, the strong positive effects of hesperidin administration on diabetic toxicity in the liverand kidneys suggest that it may be included in the alternative treatment methods in the future.
dc.description.sponsorshipThis work was supported by Coordinator of Scientific Research Projects ( 2017.M83.02.01 ) at University of Artvin Coruh.en_US
dc.identifier.citationDokumacıoğlu, E., İskender, H., & Musmul, A. (2019). Effect of hesperidin treatment on α-Klotho/FGF-23 pathway in rats with experimentally-induced diabetes. Biomedicine & Pharmacotherapy, 109, 1206-1210. Doi: 10.1016/j.biopha.2018.10.192en_US
dc.identifier.doi10.1016/j.biopha.2018.10.192
dc.identifier.endpage1210en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage1206en_US
dc.identifier.urihttps://hdl.handle.net/11494/2399
dc.identifier.volume109en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorİskender, Hatice
dc.institutionauthorDokumacıoğlu, Eda
dc.language.isoenen_US
dc.publisherElsevier Masson SASen_US
dc.relation.ispartofBiomedicine and Pharmacotherapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlpha-Klothoen_US
dc.subjectDiabetes mellitusen_US
dc.subjectFibroblast growth factor-23en_US
dc.subjectHesperidinen_US
dc.subjectLipid peroxidationen_US
dc.titleEffect of hesperidin treatment on α-Klotho/FGF-23 pathway in rats with experimentally-induced diabetesen_US
dc.typeArticle

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