Curcumin exerts protective effects against valproic acid-induced testicular damage through modulating the JAK1/STAT–3/IL–6 signaling pathway in rats

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dc.authorid0000-0002-2223-1331
dc.authorid0000-0002-8063-4972
dc.authorid0000-0003-1398-7046
dc.authorid0000-0002-1740-8657
dc.authorid0000-0002-9075-7239
dc.authorid0000-0002-2976-4368
dc.authorid0000-0002-4446-0848
dc.contributor.authorDokumacıoğlu, Eda
dc.contributor.authorİskender, Hatice
dc.contributor.authorTerim Kapakin, Kübra Asena
dc.contributor.authorBolat, İsmail
dc.contributor.authorMokhtare, Behzat
dc.contributor.authorÖmür, Ali Doğan
dc.contributor.authorHayırlı, Armağan
dc.date.accessioned2025-03-10T05:46:00Z
dc.date.available2025-03-10T05:46:00Z
dc.date.issued2025
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractObjective(s): This experiment was carried out to investigate the protective effects of curcumin (CUR) on testicular damage induced by the valproic acid (VPA) administration. Materials and Methods: Male Wistar-Albino rats (n=28, 250-300 g) were randomly divided into four groups: Control (1 ml saline, oral), VPA (500 mg/kg, IP), CUR (200 mg/kg, oral), or VPA+CUR (500 mg/kg, VPA, IP plus 200 mg/kg CUR, oral). The treatments were applied for 14 days. Serum testosterone and testis [Janus kinases1 (JAK1), signal transducers and activators of transcription-3 interleukin-18 (IL-18), and nuclear factor (NF)-kappa B)] samples were collected for biochemical analyses. Semen samples were subjected to microscopy for spermatological parameters. Testis tissue was also analyzed for histopathological and immunohistochemical methods. Results: The VPA administration caused a 37% decrease in serum testosterone concentration and 5.32, 9.51, 2.44, and 3.68-fold increases in testicular tissue JAK1, STAT-3, IL-6, and MDA levels, respectively. There were also 50, 52, and 72% reductions in sperm motility, sperm viability, and the mean testicular biopsy score, respectively, accompanied by considerable degenerative changes and necrosis in seminiferous tubules in the VPA group. There is also an immune-positive reaction for IL-18 and NF-kappa B in only Leydig cells. Conclusion: The CUR treatment may be beneficial in restoring testicular damage through antiinflammatory and anti-oxidant potential.
dc.identifier.citationDokumacioglu E, Iskender H, Kapakin KAT, Bolat İ, Mokhtare B, Omur AD, Hayirli A. Curcumin exerts protective effects against valproic acidinduced testicular damage through modulating the jak1/stat–3/il–6 signaling pathway in rats. Iran J Basic Med Sci 2025; 28: 230-236. doi: https://dx.doi.org/10.22038/ijbms.2024.76948.16659
dc.identifier.doi10.22038/ijbms.2024.76948.16659
dc.identifier.endpage236
dc.identifier.issn2008-3866
dc.identifier.issue2
dc.identifier.pmid39850114
dc.identifier.scopus2-s2.0-85214461495
dc.identifier.scopusqualityQ3
dc.identifier.startpage230
dc.identifier.urihttps://hdl.handle.net/11494/5431
dc.identifier.volume28
dc.identifier.wosWOS:001379175400011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDokumacıoğlu, Eda
dc.institutionauthorİskender, Hatice
dc.institutionauthorid0000-0002-2223-1331
dc.institutionauthorid0000-0002-8063-4972
dc.language.isoen
dc.publisherMASHHAD UNIV MED SCIENCES
dc.relation.ispartofIRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.titleCurcumin exerts protective effects against valproic acid-induced testicular damage through modulating the JAK1/STAT–3/IL–6 signaling pathway in rats
dc.typeArticle

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