Detection of class 1 integron in Acinetobacter baumannii isolates collected from nine hospitals in Turkey

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dc.contributor.authorÇopur Çiçek, Ayşegül
dc.contributor.authorDüzgün, Azer Özad
dc.contributor.authorSaral Sarıyer, Ayşegül
dc.contributor.authorKayman, Tuba
dc.contributor.authorÇizmeci, Zeynep
dc.contributor.authorBalcı, Pervin Özlem
dc.contributor.authorDal, Tuba
dc.contributor.authorFırat, Mehmet
dc.contributor.authorTosun, İsmail
dc.contributor.authorAy Altıntop, Yasemin
dc.date.accessioned2025-07-03T07:34:30Z
dc.date.available2025-07-03T07:34:30Z
dc.date.issued2013
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractObjective: To investigate the antibiotic resistance genes inserted into class 1 and class 2 integrons in Acinetobacter baumannii (A. baumannii) isolates obtained from nine different cities in Turkey. Methods: A collection of 281 A. baumannii clinical isolates were collected from nine diferent state hospitals in Turkey and were confirmed as A. baumannii by conventional biochemical, API testing and bla-OXA-51 specific PCR. The isolates were examined by PCR for existence of class 1 and 2 integron gene cassettes. Results: They were characterized by antimicrobial susceptibility testing and the highest resistance rates were determined for piperacillin (90.03%), ciprofloxacin (87.54%), cefepime and trimethoprim/sulfamethoxazole (81.13%). The lowest resistance rates was for cefotaxime (3.55%). class I integrons were detected in 6.4% (18/281) of A. baumannii strains and no class 2 integron was detected. The gene cassettes of class 1 integrons AacC1-AAC(3) I-aadA1, AacC1-aadA1, AAC(3)-I, AAC(3)-I -AAC(3)-I -aadA1, TEM-1, AAC(3)-I-aadA1 - AAC(3)-I -AAC(3)-I, AAC(3)-I -AAC(3)-I -AAC(3)-I -aadA1, AAC(3)-I - aadA1, AAC(3)-I-AAC(3)-I, AAC(3)-I-aadA1-AAC(3)-I-aadA1, AAC(3)-I-AAC(3)-I-aadA1-AAC(3)-I-aadA1 were detected in eighteen strains. The aac genes family were most frequently found integrated into the class 1 integrons and it was followed by aadA genes and TEM-1 genes. Conclusions: This is an extensive study on the distribution of class 1 integron among A. baumannii in Turkey. In addition to these, two new alleles were observed. Their percentage rates of similarity to other cassettes are 95% aadA1 (TKA18) and 89% aadA1 (ANKA3).
dc.identifier.doi10.1016/S2221-1691(13)60149-5
dc.identifier.endpage747
dc.identifier.issn22211691
dc.identifier.issue9
dc.identifier.pmid23998017
dc.identifier.scopus2-s2.0-84883257201
dc.identifier.scopusqualityQ2
dc.identifier.startpage743
dc.identifier.urihttps://hdl.handle.net/11494/5652
dc.identifier.volume3
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSaral Sarıyer, Ayşegül
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofAsian Pacific Journal of Tropical Biomedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcinetobacter baumannii
dc.subjectClass 1 integron
dc.subjectGene cassette
dc.subjectResistance
dc.titleDetection of class 1 integron in Acinetobacter baumannii isolates collected from nine hospitals in Turkey
dc.typeArticle

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