Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?

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dc.authorid0000-0001-8567-807Xen_US
dc.authorid0000-0002-7261-6790en_US
dc.authorid0000-0003-3251-1043en_US
dc.contributor.authorBayramoğlu, Ayşegül
dc.contributor.authorKüçük, Meral Urhan
dc.contributor.authorGüler, Halil İbrahim
dc.contributor.authorAbacı, Okay
dc.contributor.authorKüçükkaya, Yunus
dc.contributor.authorÇolak, Ertuğrul
dc.date.accessioned2020-11-13T11:37:40Z
dc.date.available2020-11-13T11:37:40Z
dc.date.issued2015
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.description.abstractThe current study was conducted to determine whether there is a relation between hypertension and two different polymorphisms, including C1562T of the Matrix metalloproteinase-9 (MMP-9) gene and C677T of the methylenetetrahydrofolate reductase (MTHFR) gene. Genomic DNA obtained from 224 persons (125 patients with hypertension and 99 healthy controls) were used in the study. Polymorphisms were determined by using polymerase chain reaction-restriction fragment length polymorphism and electrophoresis. The results were statistically analyzed and were found to be statistically significant. The frequencies of the C1562T genotypes were found to be, in controls CC 75.8 % and CT 24.2 % and in patients CC 71.2 %, and CT 28.8 %. The frequencies of C677T genotype were found to be, in controls CC 56.6 %, CT 38.4 and TT 5.1 % in controls and in patients CC 52 %, CT 30.4 % and TT 17.6 %. In conclusion, we may suggest that there is no relation between the essential hypertension and C1562T polymorphism of MMP-9 gene; on the other hand C677T polymorphism (genotype TT) of MTHFR gene can be regarded as a genetic indicator for the development of essential hypertension.
dc.description.sponsorshipMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT), Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research (KAKENHI): 24501322en_US
dc.identifier.citationBayramoğlu, A., Küçük, M. U., Güler, H. I., Abaci, O., Küçükkaya, Y., & Çolak, E. (2015). Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?. Cytotechnology, 67(1), 115-122.en_US
dc.identifier.doi10.1007/s10616-013-9665-0
dc.identifier.endpage122en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage115en_US
dc.identifier.urihttps://hdl.handle.net/11494/2457
dc.identifier.volume67en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBayramoğlu, Ayşegül
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCytotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEssential hypertensionen_US
dc.subjectMMP-9en_US
dc.subjectMMP-9 C1562T polymorphismen_US
dc.subjectMTHFRen_US
dc.subjectMTHFR C677T polymorphismen_US
dc.titleIs there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?en_US
dc.typeArticle

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