Frequency of angiotensin II type 1 receptor gene polymorphism in Turkish acute stroke patients

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dc.authorid0000-0001-8567-807Xen_US
dc.contributor.authorKurt, Hülyam
dc.contributor.authorBayramoğlu, Ayşegül
dc.contributor.authorGüneş, Hasan Veysi
dc.contributor.authorÖzbabalık, Demet
dc.contributor.authorDeğirmenci, İrfan
dc.contributor.authorÇolak, Ertuğrul
dc.contributor.authorCoşan Turgut, Didem
dc.contributor.authorBayram, Banu
dc.contributor.authorDikmen, Miris
dc.date.accessioned2021-12-09T07:07:35Z
dc.date.available2021-12-09T07:07:35Z
dc.date.issued2013
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractThis study was performed in acute stroke patients in the Turkish population to determine the frequency of the A1166C polymorphism in the AT1 gene and to examine the role of this polymorphism in acute stroke development. In this study, 257 genomic DNA samples were analysed (from 206 acute stroke patients and 51 healthy individuals). Genomic DNA was prepared from peripheral blood using the salt-extraction method. The presence of the A1166C polymorphism in the AT1 gene was determined using the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method. PCR products were separated by 2% agarose gel electrophoresis and visualized by a charge-coupled device (CCD) camera. In this study, the allele frequency at the A1166C position was 92% A and 8% C for control and 97% A and 3% C for patients. This difference in allele frequency between the control group and the patient group was not statistically significant. However, genotype and allele frequencies showed a significant difference (P<0.001) in the control and the patient groups. The results of this study show no relationship between the A1166C polymorphism in the AT1 gene and acute stroke in the Turkish population.
dc.identifier.citationHulyam, K., Ayşegül, B., Veysi, G. H., Demet, O., İrfan, D., Ertuğrul, C., ... & Miris, D. (2013). Frequency of angiotensin II type 1 receptor gene polymorphism in Turkish acute stroke patients. Journal of cellular and molecular medicine, 17(4), 475-481.en_US
dc.identifier.doi10.1111/jcmm.12017
dc.identifier.endpage481en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage475en_US
dc.identifier.urihttps://hdl.handle.net/11494/3596
dc.identifier.volume17en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBayramoğlu, Ayşegül
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Cellular and Molecular Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectacute strokeen_US
dc.subjectAT1 geneen_US
dc.subjectA1166C polymorphismen_US
dc.titleFrequency of angiotensin II type 1 receptor gene polymorphism in Turkish acute stroke patientsen_US
dc.typeArticle

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