Effect of white tea consumption on serum leptin, TNF-α and UCP1 gene expression in ovariectomized rats
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
John Libbey
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Obesity and dyslipidemia due to estrogen deficiency are among the important health problems in menopausal women. Increasing evidence reports the anti-obesity and anti-hyperlipidemic properties of tea polyphenols. However, the effect of white tea (WT) with high polyphenol content on overweight and lipid profile is uncertain. Here, we aimed to examine the effects of long-term WT consumption on serum leptin, tumor necrosis factor- alpha (TNF-?) and uncoupling protein 1 (UCP1) mRNA gene expression in ovariectomized (OVX) rats. Methods: Adult rats were divided into four groups (n = 8): (i) sham, (ii) OVX, (iii) WT and (iv) OVX + WT. WT was given at a dose of 0.5% w/v for 12 weeks. In the study, body weight, serum leptin, TNF, estradiol (E2) levels, lipid profile and UCP1 mRNA gene expression in brown adipose tissue (BAT) were evaluated. Results: There was a significant increase in body weight of OVX rats, which was decreased following WT consumption. While leptin and E2 levels decreased in the OVX group, TNF levels increased. There was no difference between the NF-?B levels of the groups. In addition, BAT UCP1 mRNA expression was significantly decreased in OVX groups, while WT treatment stimulated UCP1 activity. Conclusion: We explain the stimulatory effect of WT on weight loss mainly by the induction of UCP1 gene-mediated thermogenesis and suppression of inflammation. Therefore, we suggest that prolonged WT consumption may have beneficial effects in limiting excess weight gain caused by estrogen deficiency.
Açıklama
Anahtar Kelimeler
Body weight, Ovariectomized, TNF-α, UCP1, White tea
Kaynak
European Cytokine Network
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
32
Sayı
2
Künye
Saral, S., Saydam, F., Dokumacioglu, E., Atak, M., Tümkaya, L., & Uydu, H. A. (2021). Effect of white tea consumption on serum leptin, TNF-α and UCP1 gene expression in ovariectomized rats. European Cytokine Network, 32(2), 31-38.
