Protective effect of chitosan treatment against acetaminophen-induced hepatotoxicity

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dc.authorid0000-0002-4966-1745en_US
dc.contributor.authorÖzçelik, Eda
dc.contributor.authorUslu, Sema
dc.contributor.authorErkasap, Nilufer
dc.contributor.authorKarimi, Hadi
dc.date.accessioned2020-11-05T13:47:51Z
dc.date.available2020-11-05T13:47:51Z
dc.date.issued2014
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.description.abstractAcetaminophen (APAP) is the most commonly reported toxic ingestion in the world. Severe liver injury resulting from overdose or chronic use of APAP remains a significant clinical problem. In recent years, the mechanisms underlying liver injury caused by APAP have become much better understood. We have studied the protective effect of chitosan supplementation against APAP-induced hepatotoxicity with respect to changes in the levels of total and lipidbound sialic acid in the serum and in the liver tissue and changes in the activity of diagnostic marker enzymes, lipid peroxidation, and ceruloplasmin oxidase enzyme in normal and experimental groups of rats. During the experimental period, chitosan (200 mg/kg body weight per day) was administered to APAP ? chitosan-treated rats by oral gavage. Results showed that treatment with APAP induced a significant increase in the serum alanine aminotransferase and alkaline phosphatase activities, in total and lipid-bound sialic acids levels, and in the liver lipid peroxide content. The administration of chitosan significantly prevented APAP-induced alterations in the levels of diagnostic marker enzymes, total sialic acid, lipid-bound sialic acid, and malondialdehyde in the experimental groups of rats. Furthermore, chitosan administration increased the activity of ceruloplasmin oxidase. In conclusion, our results suggest that chitosan has a protective effect on APAP-induced hepatic injury in rats. The study sheds light on the therapeutic potential of chitosan in an APAP-induced hepatotoxicity model.
dc.identifier.citationÖzçelik, E., Uslu, S., Erkasap, N., & Karimi, H. (2014). Protective effect of chitosan treatment against acetaminophen-induced hepatotoxicity. The Kaohsiung Journal of Medical Sciences, 30(6), 286-290.en_US
dc.identifier.doi10.1016/j.kjms.2014.02.003
dc.identifier.endpage290en_US
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage286en_US
dc.identifier.urihttps://hdl.handle.net/11494/2417
dc.identifier.volume30en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzçelik, Eda
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofKaohsiung Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcetaminophenen_US
dc.subjectChitosanen_US
dc.subjectHepatotoxicityen_US
dc.subjectSialic aciden_US
dc.titleProtective effect of chitosan treatment against acetaminophen-induced hepatotoxicityen_US
dc.typeArticle

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