The biochemical and histological effects of lichens in normal and diabetic rats

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dc.contributor.authorDeniz, Gülşah Yıldız
dc.contributor.authorGeyikoğlu, Fatime
dc.contributor.authorTürkez, Hasan
dc.contributor.authorBakır, Tülay Özhan
dc.contributor.authorÇolak, Suat
dc.contributor.authorAslan, Ali
dc.date.accessioned2020-11-12T10:25:34Z
dc.date.available2020-11-12T10:25:34Z
dc.date.issued2016
dc.departmentAÇÜ, Rektörlüken_US
dc.description.abstractOxidative stress plays an important role in causing diabetes; however, no studies have thoroughly reported on the toxic and beneficial effects of lichen extracts in patients with diabetes mellitus (DM). This study covers a previously unrecognized effect of two well-known lichen species Cetraria islandica and Pseudevernia furfuracae in streptozotocin (STZ)-induced diabetes. In experimental design, control or diabetic rats were either untreated or treated with aqueous lichen extracts (250-500 mg/kg /day) for 2 weeks starting at 72 h after STZ injection. On day 14, animals were anaesthetized, and metabolic and biochemical parameters were appreciated between control and treatment groups. The histopathology of liver was examined using three different staining methods: hematoxylin-eosin (H&E), periodic acid Schiff (PAS), and reticulin and Sudan Black B. Our experimental data showed that increasing doses of C. islandica and P. furfuracae alone did not have any detrimental effects on studied parameters and the malondialdehyde level of liver. C. islandica extract showed positive results for antioxidant capacity compared to doses of P. furfuracae extract. However, the protective effect of C. islandica extract on diabetes-induced disorders and hepatic damages is still unclear. Moreover, unfortunately, animals subjected to DM therapy did not benefit from the usage of increasing lichen doses due to their unchanged antioxidant activity in tissues. The results obtained in present study suggested that C. islandica and P. furfuracae is safe but the power of these is limited because of intensive oxidative stress in liver of type 1 diabetic rats. It is also implied that C. islandica extract is especially suitable for different administration routes in DM animals.
dc.identifier.citationDeniz, G. Y., Geyikoğlu, F., Türkez, H., Bakır, T. Ö., Çolak, S., & Aslan, A. (2016). The biochemical and histological effects of lichens in normal and diabetic rats. Toxicology and Industrial Health, 32(4), 601-613.en_US
dc.identifier.doi10.1177/0748233713506769
dc.identifier.endpage613en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage601en_US
dc.identifier.urihttps://hdl.handle.net/11494/2446
dc.identifier.volume32en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇolak, Suat
dc.language.isoenen_US
dc.publisherSage Publicationsen_US
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCetraria islandicaen_US
dc.subjectPseudevernia furfuracaeen_US
dc.subjectDiabetes mellitusen_US
dc.subjectLiveren_US
dc.subjectHistologyen_US
dc.subjectOxidative stressen_US
dc.titleThe biochemical and histological effects of lichens in normal and diabetic ratsen_US
dc.typeArticle

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