White tea reduced bone loss by suppressing the TRAP/CTX pathway in ovariectomy-induced osteoporosis model rats

Basit Öğe Kaydı
dc.contributor.authorYıldırım, Murat
dc.contributor.authorMercantepe, Tolga
dc.contributor.authorİskender, Hatice
dc.contributor.authorTümkaya, Levent
dc.contributor.authorAtak, Mehtap
dc.contributor.authorTaşçı, Filiz
dc.date.accessioned2020-06-29T06:00:55Z
dc.date.available2020-06-29T06:00:55Z
dc.date.issued2020
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.description.abstractOsteoporosis is an important skeletal disease characterized by bone weakness and high risk of fracture in postmenopausal women. Tea consumption is known to play an important role in the prevention or alleviation of osteoporosis. However, the therapeutic effects of aqueous extracts of white tea (WT) have not been evaluated in osteoporosis rat models. The aim of this study was to investigate the potential anti-osteoporotic role of WT in ovariectomized (OVX) rats. WT was given orally at 0.5% w/v doses for 12 weeks in OVX rats. Biochemical parameters in blood samples, bone tartrate-resistant acid phosphatase (TRAP), C-terminal telopeptide of type 1 collagen (CTX) and estradiol levels were evaluated. Bone mineral density and bone mineral content values were measured in the left femur. In addition to histopathological examination, osteolcalcin, osteopontin and TUNEL levels were determined. OVX group data demonstrated that bone loss occurred by thinning of the metaphyseal growth plates of the femur. Similarly, the levels of TRAP and CTX, markers of osteoclastic activity, were found to be high concurrently with a decrease in femoral bone mineral density. In addition, increased osteolcalcin and osteopontin levels were present in the metaphyseal growth zones. On the other hand, while TRAP and CTX levels were suppressed in the OVX-WT group, bone mineral content increased. In ad­dition, TUNEL, osteocalcin and osteopontin positivity decreased in the right femoral metaphysis growth zones, proliferating zone and resting zone cells. These results showed that chronic WT consumption has a protective effect by reducing bone resorption in OVX-induced osteoporotic rats.
dc.identifier.citationYıldırım, M., Saral, S., Mercantepe, T., İskender, H., Tümkaya, L., Atak, M., & Taşçı, F. (2020). White Tea Reduced Bone Loss by Suppressing the TRAP/CTX Pathway in Ovariectomy-Induced Osteoporosis Model Rats. Cells Tissues Organs, 209(1), 64-74. DOI: 10.1159/000507791.en_US
dc.identifier.doi10.1159/000507791
dc.identifier.endpage74
dc.identifier.issue1
dc.identifier.scopusqualityQ1
dc.identifier.startpage64
dc.identifier.urihttps://hdl.handle.net/11494/2127
dc.identifier.volume209
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorİskender, Hatice
dc.language.isoenen_US
dc.publisherNLM (Medline)en_US
dc.relation.ispartofCells Tissues Organs
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone lossen_US
dc.subjectC-terminal telopeptide of type 1 collagenen_US
dc.subjectOvariectomyen_US
dc.subjectTartrate-resistant acid phosphataseen_US
dc.subjectWhite teaen_US
dc.titleWhite tea reduced bone loss by suppressing the TRAP/CTX pathway in ovariectomy-induced osteoporosis model ratsen_US
dc.typeArticle

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Beslenme ve Diyetetik Bölümü Yayın Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu