Effect of betulinic acid administration on tlr-9/nf-κb /il-18 levels in experimental liver injury

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dc.authorid0000-0002-2223-1331en_US
dc.authorid0000-0002-8063-4972en_US
dc.contributor.authorDokumacıoğlu, Eda
dc.contributor.authorİskender, Hatice
dc.contributor.authorTerim Kapakin, Kübra Asena
dc.contributor.authorYenice, Güler
dc.contributor.authorMokthare, Behzat
dc.contributor.authorBolat, İsmail
dc.contributor.authorHayırlı, Armağan
dc.date.accessioned2021-08-05T13:03:04Z
dc.date.available2021-08-05T13:03:04Z
dc.date.issued2021
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractBackground/aim: Acetaminophen (APAP), used in the composition of thousands of preparations, is the most commonly used analgesic and antipyretic drug. The present study aimed to investigate the potential protective effects of the betulinic acid (BA) treatment through an APAP-induced hepatotoxicity rat model, using inflammatory, biochemical, and histopathological parameters. Materials and methods: The study consisted of four groups: control group, APAP group, BA group, and APAP+BA group. Experimental studies continued for fifteen days. Serum samples were analysed for glucose, total cholesterol (TChol), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), aspartate amino transferase (AST), malondialdehyde (MDA), toll-like receptor-9 (TLR-9), nuclear factor kappa B (NF-kappa B), and interleukin-18 (IL-18). Results: TLR9, IL-18, NF-kappa B, and MDA levels increased significantly in liver injury groups. These increases considerably decreased by the BA treatment. All groups showed immunopositivity for 8-hydroxy-2 & rsquo;& ndash;deoxyguanosine (8-OHdG) and interleukin (IL-1 beta) in the hepatocytes, inflammatory cells, and epithelial cells of bile ducts. Conclusion: BA can be used as an effective agent in the prevention and treatment of acute liver diseases due to its inhibitory properties in multiple pathways and its potent antioxidant effects.
dc.description.sponsorshipCoordinator of Scientific Research Projects at the University of Artvin Coruh 2018.M83.02.01en_US
dc.identifier.citationDokumacıoğlu, E., İskender, H., Kapakin, K. A. T., Yenice, G., Mokthare, B., Bolat, I., & Hayırlı, A. (2021). Effect of betulinic acid administration on TLR-9/NF-? B/IL-18 levels in experimental liver injury. Turkish Journal of Medical Sciences, 51(3), 1544-1553.en_US
dc.identifier.doi10.3906/sag-2004-184
dc.identifier.endpage1553en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage1544en_US
dc.identifier.urihttps://hdl.handle.net/11494/3305
dc.identifier.volume51en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorDokumacıoğlu, Eda
dc.institutionauthorİskender, Hatice
dc.language.isoenen_US
dc.publisherTUBITAK Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcetaminophenen_US
dc.subjectBetulinic aciden_US
dc.subjectInterleukin-18en_US
dc.subjectNuclear factor kappa Ben_US
dc.subjectToll-like receptor-9en_US
dc.titleEffect of betulinic acid administration on tlr-9/nf-κb /il-18 levels in experimental liver injuryen_US
dc.typeArticle

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