The determination of the carbonic anhydrases activators in vitro effect of mixed donor crown ethers

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dc.authorid0000-0002-4177-4884en_US
dc.authorid0000-0001-7699-2008en_US
dc.contributor.authorAkkemik, Ebru
dc.contributor.authorÇiçek, Baki
dc.contributor.authorCamadan, Yasemin
dc.contributor.authorÇalışır, Ümit
dc.contributor.authorOnbaşıoğlu, Zekai
dc.date.accessioned2020-11-06T08:23:24Z
dc.date.available2020-11-06T08:23:24Z
dc.date.issued2018
dc.departmentAÇÜ, Sağlık Hizmetlerien_US
dc.description.abstractCarbonic anhydrases (CAs) play an important function in various physiological and pathological processes. Therefore, many researchers work in this field in order to design and synthesize new drugs. Both inhibitors and activators of CAs, which are associated with the diagnosis and treatment of many diseases, are very important. The emergence of the use of CA activators in the treatment of Alzheimer has led many scholars to work on this issue. In this study, CA activators and inhibitors are determined. The crown ethers compounds (1, 2, 3, 6, 7, 8, and 9) were found to cause activation on enzyme activities of hCA I and II. The AC50 values on hCA I and II of the compounds are in the range of 4.6565-374.979 ?M. The 4 (IC50 ; 1.301 and 3.215 ?M for hCA I and II) and 5 (IC50 ; 73.96 and 378.5 ?M for hCA I and II) compounds were found to cause inhibition on enzyme activities of hCA I and II.
dc.identifier.citationAkkemik, E., Çiçek, B., Camadan, Y., Çalışır, U., & Onbaşıoğlu, Z. (2018). The determination of the carbonic anhydrases activators in vitro effect of mixed donor crown ethers. Journal of Biochemical and Molecular Toxicology, 32(3), e22032.en_US
dc.identifier.doi10.1002/jbt.22032
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/11494/2419
dc.identifier.volume32en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorCamadan, Yasemin
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectActivationen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectInhibitionen_US
dc.subjectMixed donor crown etheren_US
dc.titleThe determination of the carbonic anhydrases activators in vitro effect of mixed donor crown ethersen_US
dc.typeArticle

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