Phytochemical investigation, antimicrobial activities, and molecular docking studies on endemic Gelasia sericea (Aucher ex DC.) Zaika, Sukhor. & N.Kilian grown in Türkiye

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dc.contributor.authorBozdal, Gözde
dc.contributor.authorKorkmaz, Büşra
dc.contributor.authorAbanoz, Murat Emre
dc.contributor.authorŞahin, Büşra
dc.contributor.authorUzuner, Uğur
dc.contributor.authorBozdeveci, Arif
dc.contributor.authorMakbul, Serdar
dc.contributor.authorYaylı, Nurettin
dc.date.accessioned2026-07-08T11:16:57Z
dc.date.available2026-07-08T11:16:57Z
dc.date.issued2025
dc.departmentAÇÜ, Rektörlük, Proje Koordinasyon Uygulama ve Araştırma Merkezi
dc.description.abstractn this study, activity-guided isolation of the endemic Gelasia sericea (Aucher ex DC.) Zaika, Sukhor. & N.Kilian yielded five new compounds (8-O-β-D-glucopyranosyl-6-hydroxy-3-(4-hydroxyphenyl)-1H-isochromen-1-one (1), rel. (3 R,3′S)-8,8’-oxybis[6-hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-isochromen-1-one] (2), 3-O-(4-O-glyceryl)-α-D-xylopyranosyl-5-methyl-4H-pyran-4-one (3), 2-carboxyl-3-hydroxy-4′-methoxy-5-O-(3-O-glyceryl)-β-D-xylopyranosylbibenzyl (4), and 2-carboxyl-3,4’-dihydroxy-5-O-(β-D-apiofuranosyl)-(1→6)-β-D-glucopyranosylbibenzyl (5). Five known compounds as p-coumaric acid (6), scorzopigmecosite (7), scorzocreticin (8), quercetin (9), and kelampayoside A (10). Spectroscopic methods were used to characterise the structures of compounds 1–10. All the isolated compounds, except compound 10, exhibited an inhibition zone diameter of 10–12 mm against at least one of the nine different microorganisms tested. Compound 8 was found to be the most effective with an MIC value of 12.5 μg/mL against Pseudomonas aeruginosa. Additionally, molecular docking analysis of compounds 1–10 was performed, targeting P. aeruginosa RhlR and DNA gyrase B enzymes. Among the identified compounds, compound 2 exhibited the most promising inhibitory activity against both targets, with binding energies of −12.0 and −11.3 kcal/mol, respectively.
dc.identifier.doi10.1080/14786419.2025.2571858
dc.identifier.issn14786419
dc.identifier.scopus2-s2.0-105019705744
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/11494/6276
dc.identifier.wosWOS:001600304800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorŞahin, Büşra
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofNatural Product Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntimicrobial
dc.subjectChromatography
dc.subjectDocking study
dc.subjectGelasia sericea (Aucher ex DC.) Zaika
dc.subjectIsolation
dc.subjectSukhor. & N.Kilian
dc.titlePhytochemical investigation, antimicrobial activities, and molecular docking studies on endemic Gelasia sericea (Aucher ex DC.) Zaika, Sukhor. & N.Kilian grown in Türkiye
dc.typeArticle

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