Effects of oleanolic acid administration on renal NF-κB/IL-18/ IL-6 and YKL-40/KIM-1 pathways in experimental diabetic rats

Basit Öğe Kaydı
dc.authorid0000-0002-8063-4972
dc.authorid0000-0002-2223-1331
dc.authorid0000-0002-4446-0848
dc.authorid0000-0002-1740-8657
dc.authorid0000-0003-1398-7046
dc.authorid0000-0003-3877-7686
dc.contributor.authorİskender, Hatice
dc.contributor.authorDokumacıoğlu, Eda
dc.contributor.authorHayirli, Armagan
dc.contributor.authorKapakin, Kubra Asena Terim
dc.contributor.authorBolat, Ismail
dc.contributor.authorKirman, Esra Manavoglu
dc.date.accessioned2025-07-25T12:23:48Z
dc.date.available2025-07-25T12:23:48Z
dc.date.issued2023
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractObjective(s): Neuropathy, retinopathy, and nephropathy, known as the triopathy of diabetes, are the consequences of microvascular complications of diabetes. The present study aimed to investigate the potential protective effects of oleanolic acid (OA) administration against diabetic nephropathy considering biochemical and histopathological parameters. Materials and Methods: The rats with fasting blood glucose levels of 200 mg/dl and above were considered diabetic after induction of diabetes via injecting STZ. The other half of the rats were not injected with STZ (healthy rats). Both healthy and diabetic rats were then divided randomly into two subgroups to be administered with either OA (5 mg/kg) with 1 ml tap water by oral gavage or 1 ml tap water in the same route for 21 days. Serum urea-N, Ca, P, and Mg as well as renal tissue MDA, SOD, NF-κB, IL-6, IL-18, AMPK, YKL-40, and KIM-1 levels were measured. Results: OA administration partially decreased levels of serum urea-N and P, as well as levels of renal tissue MDA and inflammation markers (NF-κB, IL-6, IL-18, YKL-40, and KIM-1) in the diabetic rats. It also partially increased serum Ca and renal tissue AMPK levels in diabetic rats. These positive effects were also seen in renal tissue histopathology. Conclusion: OA treatment partially alleviated renal damage inflammatory and oxidative profiles in diabetic rats.
dc.identifier.doi10.22038/IJBMS.2023.71321.15504
dc.identifier.endpage1193
dc.identifier.issn20083866
dc.identifier.scopus2-s2.0-85179045285
dc.identifier.scopusqualityQ2
dc.identifier.startpage1188
dc.identifier.urihttps://hdl.handle.net/11494/5893
dc.identifier.volume26
dc.indekslendigikaynakScopus
dc.institutionauthorİskender, Hatice
dc.institutionauthorDokumacıoğlu, Eda
dc.institutionauthorid0000-0002-8063-4972
dc.institutionauthorid0000-0002-2223-1331
dc.language.isoen
dc.publisherMashhad University of Medical Sciences
dc.relation.ispartofIranian Journal of Basic Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCytokines
dc.subjectDiabetes
dc.subjectKIM-1
dc.subjectOleanolic acid
dc.subjectYKL-40
dc.titleEffects of oleanolic acid administration on renal NF-κB/IL-18/ IL-6 and YKL-40/KIM-1 pathways in experimental diabetic rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
5893.pdf
Boyut:
713.36 KB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Beslenme ve Diyetetik Bölümü Yayın Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu