Protective role of Diospyros lotus on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats

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dc.authorid0000-0002-6494-9229en_US
dc.authorid0000-0001-5755-3560en_US
dc.contributor.authorSaral, Sinan
dc.contributor.authorÖzçelik, Eda
dc.contributor.authorSaral, Özlem
dc.contributor.authorBaşak, Neşe
dc.contributor.authorÇiftçi, Osman
dc.contributor.authorAydın, Muhterem
dc.date.accessioned2020-11-16T07:01:25Z
dc.date.available2020-11-16T07:01:25Z
dc.date.issued2016
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.description.abstractThe aim of this study was to investigate the protective effect of Diospyros lotus (DL) on cisplatin (CP)-induced testicular damage in male rats. Twenty-eight male rats were randomly divided into four groups: group 1 - control, given isotonic saline solution; group 2 - CP 7mgkg(-1) given intraperitoneally as single dose; group 3 - DL 1000mgkg(-1) per day given orally for 10days; group 4 - CP and DL given together at the same doses. CP caused a significant increase in thiobarbituric acid-reactive substances (TBARS) level and a significant decrease in superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and glutathione (GSH) levels in rats testis tissues compared to the control group. CP caused a significant increase in lipid peroxidation in testis tissues compared to the control group, whereas DL led to a significant increase in SOD and GSH levels. However, there were no statistically significant changes in GPx and CAT levels. In addition, serum testosterone levels, sperm concentration and sperm motility were significantly decreased, but abnormal sperm rate and histological changes were increased with CP. However, these effects of CP on sperm parameters, histological changes and the tissue weights were eliminated by DL treatment. In conclusion, our study showed that the reproductive toxicity caused by CP may be prevented by DL treatment.
dc.identifier.citationSaral, S., Özçelik, E., Çetin, A., Saral, O., Başak, N., Aydın, M., & Çiftci, O. (2016). Protective role of diospyros lotus on cisplatin‐induced changes in sperm characteristics, testicular damage and oxidative stress in rats. Andrologia, 48(3), 308-317.en_US
dc.identifier.doi10.1111/and.12448
dc.identifier.endpage317en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage308en_US
dc.identifier.urihttps://hdl.handle.net/11494/2459
dc.identifier.volume48en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSaral, Sinan
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectDiospyros lotusen_US
dc.subjectOxidative stressen_US
dc.subjectTesticular damageen_US
dc.titleProtective role of Diospyros lotus on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in ratsen_US
dc.typeArticle

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