Neuroprotective potential of Viburnum orientale Pallas through enzyme inhibition and antioxidant activity assays
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science BV
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Neurobiological effects of the fruit, leaf, and branch extracts of Viburnum orientale, used in the traditional drink called "gilaburi" in Anatolia, were tested against acetyl-(AChE), butyrylcholinesterase (BChE), and tyrosinase (TYR). Antioxidant effect of the extracts was determined using six in vitro methods. The fruit and branch methanol extracts with the richest total phenolic contents exerted the highest inhibition against all enzymes. These extracts were the most active in DPPH radical scavenging, ferric-(FRAP) and phosphomolibdenum-reducing antioxidant power (PRAP) assays, which was followed by the leaf aqueous extract with the best nitric oxide (75.00 +/- 1.22%), DMPD scavenging (33.70 +/- 1.13%), and metal-chelating (54.66 +/- 3.56%) effects at 2500 mu g/mL. We previously reported that the fruits are rich in chlorogenic acid, which might be related to its marked enzyme inhibitory and antioxidant effect. Our results indicated that all methanol and leaf aqueous and branch extracts of the plant are promising for their neuroprotective potential. (c) 2017 SAAB. Published by Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Viburnum orientale, Enzyme inhibition, Antioxidant activity, Neuroprotective effect, Cholinesterase, Tyrosinase
Kaynak
South African Journal of Botany
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
114
Sayı
Künye
Orhan, I. E., Şenol, F. S., Yılmaz, B. S., Altun, M. L., Özbilgin, S., Yazgan, A. N., ... & İşcan, G. S. (2018). Neuroprotective potential of Viburnum orientale Pallas through enzyme inhibition and antioxidant activity assays. South African Journal of Botany, 114, 126-131.
