Neuroprotective potential of Viburnum orientale Pallas through enzyme inhibition and antioxidant activity assays

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dc.authorid0000-0002-8171-0383en_US
dc.contributor.authorOrhan, İlkay Erdoğan
dc.contributor.authorŞenol, Fatma Sezer
dc.contributor.authorYılmaz, Betül Sever
dc.contributor.authorAltun, Mehmet Levent
dc.contributor.authorÖzbilgin, Serkan
dc.contributor.authorYazgan, A. N.
dc.contributor.authorYüksel, Emrah
dc.contributor.authorİşcan, Gülçin Saltan
dc.date.accessioned2021-04-01T08:09:27Z
dc.date.available2021-04-01T08:09:27Z
dc.date.issued2018
dc.departmentAÇÜ, Orman Fakültesien_US
dc.description.abstractNeurobiological effects of the fruit, leaf, and branch extracts of Viburnum orientale, used in the traditional drink called "gilaburi" in Anatolia, were tested against acetyl-(AChE), butyrylcholinesterase (BChE), and tyrosinase (TYR). Antioxidant effect of the extracts was determined using six in vitro methods. The fruit and branch methanol extracts with the richest total phenolic contents exerted the highest inhibition against all enzymes. These extracts were the most active in DPPH radical scavenging, ferric-(FRAP) and phosphomolibdenum-reducing antioxidant power (PRAP) assays, which was followed by the leaf aqueous extract with the best nitric oxide (75.00 +/- 1.22%), DMPD scavenging (33.70 +/- 1.13%), and metal-chelating (54.66 +/- 3.56%) effects at 2500 mu g/mL. We previously reported that the fruits are rich in chlorogenic acid, which might be related to its marked enzyme inhibitory and antioxidant effect. Our results indicated that all methanol and leaf aqueous and branch extracts of the plant are promising for their neuroprotective potential. (c) 2017 SAAB. Published by Elsevier B.V. All rights reserved.
dc.identifier.citationOrhan, I. E., Şenol, F. S., Yılmaz, B. S., Altun, M. L., Özbilgin, S., Yazgan, A. N., ... & İşcan, G. S. (2018). Neuroprotective potential of Viburnum orientale Pallas through enzyme inhibition and antioxidant activity assays. South African Journal of Botany, 114, 126-131.en_US
dc.identifier.doi10.1016/j.sajb.2017.10.023
dc.identifier.endpage131en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage126en_US
dc.identifier.urihttps://hdl.handle.net/11494/2892
dc.identifier.volume114en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYüksel, Emrah
dc.language.isoenen_US
dc.publisherElsevier Science BVen_US
dc.relation.ispartofSouth African Journal of Botany
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectViburnum orientaleen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectAntioxidant activityen_US
dc.subjectNeuroprotective effecten_US
dc.subjectCholinesteraseen_US
dc.subjectTyrosinaseen_US
dc.titleNeuroprotective potential of Viburnum orientale Pallas through enzyme inhibition and antioxidant activity assaysen_US
dc.typeArticle

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