Effects of high fructose diet on lipid metabolism and the hepatic NF-κB/ SIRT-1 pathway
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Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor and Francis Ltd.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The liver is the primary site for fructose metabolism; therefore, the liver is susceptible to fructose related metabolic disturbances including metabolic insulin dysfunction, dyslipidemia and inflammation. We investigated whether astaxanthin (ASX) can modify hepatic nuclear factorkappa B (NF-?B)/sirtuin-1 (SIRT-1) expression to alter oxidative stress caused by ingestion of excess fructose in rats. The animals were divided randomly into two x two factorially arranged groups: two regimens were given either water (W) or 30% fructose in drinking water (F). These two groups were divided further into two subgroups each: two treatments, either orally with 0.2 ml olive oil (OO) or 1 mg ASX/kg/day in 0.2 ml olive oil (ASX). Fructose administration increased serum glucose, triglycerides and very low density lipoproteins, and decreased serum concentration of high density lipoproteins; fructose did not alter serum total cholesterol. Excess fructose decreased hepatic superoxide dismutase (SOD) and increased hepatic NF-?B and MDA levels. ASX treatment increased hepatic SIRT-1 and decreased hepatic NF-?B and malondialdehyde (MDA) levels. ASX treatment decreased hepatic NF-?B and increased SOD levels, but did not alter MDA level in rats fed high fructose. ASX administration ameliorated oxidative stress caused by excess fructose by increasing hepatic NF-?B and SIRT-1 expression.
Açıklama
Anahtar Kelimeler
Astaxanthin, Fructose, Lipid, Liver, Metabolism, NF–κB, Oxidative stress, Rats, SIRT–1
Kaynak
Biotechnic and Histochemistry
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
Article in pres
Sayı
Künye
İskender, H., Yenice, G., Terim Kapakın, K. A., Dokumacıoğlu, E., Sevim, C., Hayırlı, A., & Altun, S. (2021). Effects of high fructose diet on lipid metabolism and the hepatic NF-κB/SIRT-1 pathway. Biotechnic & Histochemistry,
