Effects of high fructose diet on lipid metabolism and the hepatic NF-κB/ SIRT-1 pathway

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dc.authoridHatice İskender / 0000-0002-8063-4972en_US
dc.authoridEda Dokumacıoğlu / 0000-0002-2223-1331en_US
dc.contributor.authorİskender, Hatice
dc.contributor.authorYenice, Güler
dc.contributor.authorTerim Kapakın, Kübra Asena
dc.contributor.authorDokumacıoğlu, Eda
dc.contributor.authorÇiğdem, Sevim
dc.contributor.authorHayırlı, Armağan
dc.date.accessioned2021-03-12T13:40:42Z
dc.date.available2021-03-12T13:40:42Z
dc.date.issued2021
dc.departmentAÇÜ, Sağlık Hizmetlerien_US
dc.description.abstractThe liver is the primary site for fructose metabolism; therefore, the liver is susceptible to fructose related metabolic disturbances including metabolic insulin dysfunction, dyslipidemia and inflammation. We investigated whether astaxanthin (ASX) can modify hepatic nuclear factorkappa B (NF-?B)/sirtuin-1 (SIRT-1) expression to alter oxidative stress caused by ingestion of excess fructose in rats. The animals were divided randomly into two x two factorially arranged groups: two regimens were given either water (W) or 30% fructose in drinking water (F). These two groups were divided further into two subgroups each: two treatments, either orally with 0.2 ml olive oil (OO) or 1 mg ASX/kg/day in 0.2 ml olive oil (ASX). Fructose administration increased serum glucose, triglycerides and very low density lipoproteins, and decreased serum concentration of high density lipoproteins; fructose did not alter serum total cholesterol. Excess fructose decreased hepatic superoxide dismutase (SOD) and increased hepatic NF-?B and MDA levels. ASX treatment increased hepatic SIRT-1 and decreased hepatic NF-?B and malondialdehyde (MDA) levels. ASX treatment decreased hepatic NF-?B and increased SOD levels, but did not alter MDA level in rats fed high fructose. ASX administration ameliorated oxidative stress caused by excess fructose by increasing hepatic NF-?B and SIRT-1 expression.
dc.identifier.citationİskender, H., Yenice, G., Terim Kapakın, K. A., Dokumacıoğlu, E., Sevim, C., Hayırlı, A., & Altun, S. (2021). Effects of high fructose diet on lipid metabolism and the hepatic NF-κB/SIRT-1 pathway. Biotechnic & Histochemistry,en_US
dc.identifier.doi10.1080/10520295.2021.1890214
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1080/10520295.2021.1890214
dc.identifier.urihttps://hdl.handle.net/11494/2722
dc.identifier.volumeArticle in presen_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDokumacıoğlu, Eda
dc.institutionauthorİskender, Hatice
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofBiotechnic and Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAstaxanthinen_US
dc.subjectFructoseen_US
dc.subjectLipiden_US
dc.subjectLiveren_US
dc.subjectMetabolismen_US
dc.subjectNF–κBen_US
dc.subjectOxidative stressen_US
dc.subjectRatsen_US
dc.subjectSIRT–1en_US
dc.titleEffects of high fructose diet on lipid metabolism and the hepatic NF-κB/ SIRT-1 pathwayen_US
dc.typeArticle

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