Effect of oleanolic acid administration on hepatic AMPK, SIRT-1, IL-6 and NF-κB levels in experimental diabetes
Yükleniyor...
Dosyalar
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Link
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Diabetes mellitus (DM) is an important public health problem all over the world, considering its complications and increasing prevalence. Oleanolic acid (OA) has anti-diabetic property via modulating glucose metabolism and acting as 5?–adenosine monophosphate (AMP)–activated protein kinase (AMPK) / Sirtuin–1 (SIRT–1) activator and Interleukin 6 (IL–6) / Nuclear factor kappa B (NF–?B) inhibitor. This research questioned if the OA treatment amliorates the hepatic inflammatory profile in the diabetic rats
Açıklama
Anahtar Kelimeler
AMPK, Diabetes, Inflammation, Oleanolic acid, SIRT-1
Kaynak
Journal of Diabetes & Metabolic Disorders
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
Sayı
Künye
İskender, H., Dokumacıoğlu, E., Terim Kapakin, K. A., Bolat, I., Mokhtare, B., Hayırlı, A., & Yenice, G. (2023). Effect of Oleanolic acid administration on hepatic AMPK, SIRT-1, IL-6 and NF-κB levels in experimental diabetes. Journal of Diabetes & Metabolic Disorders.
