Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkey
Yükleniyor...
Dosyalar
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science INC
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), extensively-drug resistant (n = 5), or pan-drug resistant (n = I). PCR and DNA sequence analysis revealed that 1 strain possessed the bla(GES-5) and another carried a novel bla(VIM) variant, named VIM-38. This new gene exhibited 1 amino acid substitution (Ala265Val) in comparison to its closest variant, VIM-5. Both VIM encoding genes were clones and demonstrated similar susceptibility profile when expressed in identical background. The presence of VIM-38 increases the diversity of carbapenemases in Turkey. (C) 2014 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
Pseudomonas aeruginosa, Carbapenemase, β-lactamase, ESBL, Class 1 integron
Kaynak
Diagnostic Microbiology and Infectious Disease
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
78
Sayı
3
Künye
Iraz, M., Düzgün, A. O., Çiçek, A. C., Bonnin, R. A., Ceylan, A., Saral, A., ... & Sandallı, C. (2014). Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkey. Diagnostic Microbiology and Infectious Disease, 78(3), 292-294.
