Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkey

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dc.authorid0000-0002-6301-611Xen_US
dc.authorid0000-0002-2307-3232en_US
dc.authorid0000-0002-7757-6812en_US
dc.authorid0000-0002-1298-3687en_US
dc.contributor.authorIraz, Meryem
dc.contributor.authorDüzgün, Azer Özad
dc.contributor.authorÇopur Çiçek, Ayşegül
dc.contributor.authorBonnin, Remy A.
dc.contributor.authorCeylan, Ayşenur
dc.contributor.authorSaral, Ayşegül
dc.contributor.authorNordmann, Patrice
dc.contributor.authorSandallı, Cemal
dc.date.accessioned2020-11-13T09:05:37Z
dc.date.available2020-11-13T09:05:37Z
dc.date.issued2014
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.description.abstractPseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), extensively-drug resistant (n = 5), or pan-drug resistant (n = I). PCR and DNA sequence analysis revealed that 1 strain possessed the bla(GES-5) and another carried a novel bla(VIM) variant, named VIM-38. This new gene exhibited 1 amino acid substitution (Ala265Val) in comparison to its closest variant, VIM-5. Both VIM encoding genes were clones and demonstrated similar susceptibility profile when expressed in identical background. The presence of VIM-38 increases the diversity of carbapenemases in Turkey. (C) 2014 Elsevier Inc. All rights reserved.
dc.description.sponsorshipThis work was supported by Recep Tayyip Erdogan University Research Fund Grants BAP-2012.106.01.11 and BAP-2011.102.03.3.en_US
dc.identifier.citationIraz, M., Düzgün, A. O., Çiçek, A. C., Bonnin, R. A., Ceylan, A., Saral, A., ... & Sandallı, C. (2014). Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkey. Diagnostic Microbiology and Infectious Disease, 78(3), 292-294.en_US
dc.identifier.doi10.1016/j.diagmicrobio.2013.12.003
dc.identifier.endpage294en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage292en_US
dc.identifier.urihttps://hdl.handle.net/11494/2456
dc.identifier.volume78en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSaral, Ayşegül
dc.language.isoenen_US
dc.publisherElsevier Science INCen_US
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPseudomonas aeruginosaen_US
dc.subjectCarbapenemaseen_US
dc.subjectβ-lactamaseen_US
dc.subjectESBLen_US
dc.subjectClass 1 integronen_US
dc.titleCharacterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkeyen_US
dc.title.alternativeCharacterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing beta-lactamases in Pseudomonas aeruginosa in Turkeyen_US
dc.typeArticle

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