Mutagenic assessment of three synthetic pyridine-diaryl ketone derivatives
Yükleniyor...
Dosyalar
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sage Publications
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Nowadays, there are increasing numbers of studies about synthetic chemicals according to the supply demands of bioactive chemicals. The current study aims to investigate genotoxic potential of bioactive synthetic pyridine compounds, phenyl-3-pyridinylmethanone (1), p-tolyl-3-pyridinylmethanone (2), and 4-methoxyphenyl-3-pyridinylmethanone (3), using Ames/Salmonella and Escherichia coli WP2 bacterial reversion mutagenicity test systems. The mutant bacterial tester strains sodium azide-sensitive Salmonella typhimurium TA1535, 9-aminoacridine-sensitive S. typhimurium TA1537, and N-methyl-N-nitro-N-nitrosoguanidine-sensitive E. coli WP2uvrA were used to detect the mutagenic potential of the test compounds. The results indicated that none of the test substances showed significant mutagenic activity on S. typhimurium TA1535, TA1537, and E. coli WP2uvrA bacterial strains up to 1 mu g/plate concentrations.
Açıklama
Anahtar Kelimeler
Mutagenicity, Ames/Salmonella, E. coli WP2, Synthetic pyridine compounds
Kaynak
Toxicology and Industrial Health
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
31
Sayı
12
Künye
Özkan, H., Gültekin, D. D., Sezen, S., Ozgeriş, B., Güllüce, M., & Tümer, F. (2015). Mutagenic assessment of three synthetic pyridine-diaryl ketone derivatives. Toxicology and Industrial Health 31(12), 1252-1257.
