Mutagenic assessment of three synthetic pyridine-diaryl ketone derivatives

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dc.authorid0000-0003-0048-8248en_US
dc.authorid0000-0001-6575-6149en_US
dc.authorid0000-0002-3783-6501en_US
dc.contributor.authorÖzkan, Hakan
dc.contributor.authorGültekin, Demet Demirci
dc.contributor.authorSezen, Selma
dc.contributor.authorÖzgeriş, Bünyamin
dc.contributor.authorGüllüce, Medine
dc.contributor.authorTümer, Ferhan
dc.date.accessioned2020-11-16T12:55:43Z
dc.date.available2020-11-16T12:55:43Z
dc.date.issued2015
dc.departmentAÇÜ, Rektörlüken_US
dc.description.abstractNowadays, there are increasing numbers of studies about synthetic chemicals according to the supply demands of bioactive chemicals. The current study aims to investigate genotoxic potential of bioactive synthetic pyridine compounds, phenyl-3-pyridinylmethanone (1), p-tolyl-3-pyridinylmethanone (2), and 4-methoxyphenyl-3-pyridinylmethanone (3), using Ames/Salmonella and Escherichia coli WP2 bacterial reversion mutagenicity test systems. The mutant bacterial tester strains sodium azide-sensitive Salmonella typhimurium TA1535, 9-aminoacridine-sensitive S. typhimurium TA1537, and N-methyl-N-nitro-N-nitrosoguanidine-sensitive E. coli WP2uvrA were used to detect the mutagenic potential of the test compounds. The results indicated that none of the test substances showed significant mutagenic activity on S. typhimurium TA1535, TA1537, and E. coli WP2uvrA bacterial strains up to 1 mu g/plate concentrations.
dc.identifier.citationÖzkan, H., Gültekin, D. D., Sezen, S., Ozgeriş, B., Güllüce, M., & Tümer, F. (2015). Mutagenic assessment of three synthetic pyridine-diaryl ketone derivatives. Toxicology and Industrial Health 31(12), 1252-1257.en_US
dc.identifier.doi10.1177/0748233713491810
dc.identifier.endpage1257en_US
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage1252en_US
dc.identifier.urihttps://hdl.handle.net/11494/2464
dc.identifier.volume31en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzgeriş, Bünyamin
dc.language.isoenen_US
dc.publisherSage Publicationsen_US
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMutagenicityen_US
dc.subjectAmes/Salmonellaen_US
dc.subjectE. coli WP2en_US
dc.subjectSynthetic pyridine compoundsen_US
dc.titleMutagenic assessment of three synthetic pyridine-diaryl ketone derivativesen_US
dc.typeArticle

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