The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene
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Dosyalar
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Comenius University
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
OBJECTIVE: The aim of the present study was to reveal the possible effect of sulforaphane on oxidative stress and inflammation in rats liver with toxic hepatitis induced by acetaminophene. BACKGROUND: Sulforaphane is a compound with high antioxidant properties. Acetaminophen, which is a para-aminophenol derivative, can lead to fatal hepatic necrosis with direct hepatotoxic effects at high doses. METHODS: Thirty six male Sprague-Dawley rats were randomly divided into four groups. Control group (n = 9) was fed with standard rat chow and water for 3 days. Group APAP (n = 9) received a single dose acetaminophen 1 g/kg by oral gavage in addition to standard chow and water. Group SFN (n = 9) received sulforaphane 500 mu g/kg by oral gavage in addition to standard chow and water for 3 days. Group APAP+SFN (n = 9) received sulforaphane 500 mu g/kg and a single dose acetaminophen 1 g/kg by oral gavage in addition to standard chow and water. Acetaminophen was administered three hours after SFN administration. RESULTS: Neopterin, MDA, AST, ALT and CRP levels of group APAP were significantly increased compared to control group. GSH level of group APAP was significantly lower than in the control group. CONCLUSION: Sulforaphane is a protective agent against acetaminophen-induced liver damage and it can be added in the treatment protocol (Tab. 1, Fig. 5, Ref. 51). Text in PDF www.elis.sk.
Açıklama
Anahtar Kelimeler
Acetaminophen, Lipid peroxidation, Neopterin, Oxidative stress, Sulforaphane
Kaynak
Bratislava Medical Journal/ Bratislavske Lekarske Listy
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
118
Sayı
8
Künye
Dokumacıoğlu, E., İskender, H., Aktaş, M. S., Hanedan, B., Dokumacıoğlu, A., Şen, T. M., & Musmul, A. (2017). The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene. Bratislava Medical Journal/ Bratislavske lekarske listy, 118(8), 453-459.
