The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene

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dc.authorid0000-0002-2223-1331en_US
dc.authorid0000-0002-8063-4972en_US
dc.contributor.authorDokumacıoğlu, Eda
dc.contributor.authorİskender, Hatice
dc.contributor.authorAktaş, M. Sabih
dc.contributor.authorHanedan, Başak
dc.contributor.authorDokumacıoğlu, Ali
dc.contributor.authorŞen, Tuğba Mazlum
dc.contributor.authorMusmul, Ahmet
dc.date.accessioned2021-04-20T09:18:06Z
dc.date.available2021-04-20T09:18:06Z
dc.date.issued2017
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractOBJECTIVE: The aim of the present study was to reveal the possible effect of sulforaphane on oxidative stress and inflammation in rats liver with toxic hepatitis induced by acetaminophene. BACKGROUND: Sulforaphane is a compound with high antioxidant properties. Acetaminophen, which is a para-aminophenol derivative, can lead to fatal hepatic necrosis with direct hepatotoxic effects at high doses. METHODS: Thirty six male Sprague-Dawley rats were randomly divided into four groups. Control group (n = 9) was fed with standard rat chow and water for 3 days. Group APAP (n = 9) received a single dose acetaminophen 1 g/kg by oral gavage in addition to standard chow and water. Group SFN (n = 9) received sulforaphane 500 mu g/kg by oral gavage in addition to standard chow and water for 3 days. Group APAP+SFN (n = 9) received sulforaphane 500 mu g/kg and a single dose acetaminophen 1 g/kg by oral gavage in addition to standard chow and water. Acetaminophen was administered three hours after SFN administration. RESULTS: Neopterin, MDA, AST, ALT and CRP levels of group APAP were significantly increased compared to control group. GSH level of group APAP was significantly lower than in the control group. CONCLUSION: Sulforaphane is a protective agent against acetaminophen-induced liver damage and it can be added in the treatment protocol (Tab. 1, Fig. 5, Ref. 51). Text in PDF www.elis.sk.
dc.identifier.citationDokumacıoğlu, E., İskender, H., Aktaş, M. S., Hanedan, B., Dokumacıoğlu, A., Şen, T. M., & Musmul, A. (2017). The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene. Bratislava Medical Journal/ Bratislavske lekarske listy, 118(8), 453-459.en_US
dc.identifier.doi10.4149/BLL_2017_088
dc.identifier.endpage459en_US
dc.identifier.issue8en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage453en_US
dc.identifier.urihttps://hdl.handle.net/11494/3135
dc.identifier.volume118en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorDokumacıoğlu, Eda
dc.institutionauthorİskender, Hatice
dc.institutionauthorAktaş, M. Sabih
dc.institutionauthorHanedan, Başak
dc.institutionauthorDokumacıoğlu, Ali
dc.institutionauthorŞen, Tugba Mazlum
dc.institutionauthorMusmul, Ahmet
dc.language.isoenen_US
dc.publisherComenius Universityen_US
dc.relation.ispartofBratislava Medical Journal/ Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcetaminophenen_US
dc.subjectLipid peroxidationen_US
dc.subjectNeopterinen_US
dc.subjectOxidative stressen_US
dc.subjectSulforaphaneen_US
dc.titleThe effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminopheneen_US
dc.typeArticle

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