Bioactive compounds from rosa canina l. roots with anti-collagenase, anti-tyrosinase, and antioxidant activities: In vitro and In silico approaches

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dc.contributor.authorSubaş, Tuğba
dc.contributor.authorÖzgen, Ufuk
dc.contributor.authorKanbolat, Şeyda
dc.contributor.authorBadem, Merve
dc.contributor.authorUzuner, Uğur
dc.contributor.authorÖzdemir, Gonca
dc.contributor.authorZeytineli, Şule
dc.contributor.authorAltunışık, Şeyma
dc.contributor.authorCangul, Halide
dc.contributor.authorEminağaoğlu, Özgür
dc.date.accessioned2025-06-23T11:19:23Z
dc.date.available2025-06-23T11:19:23Z
dc.date.issued2025
dc.departmentAÇÜ, Orman Fakültesi, Orman Mühendisliği Bölümü
dc.description.abstractThe study aimed to investigate the anti-aging, skin-whitening, and antioxidant capacities of the extracts and constituents from the roots of Rosa canina L. by anti-collagenase, anti-tyrosinase activity, ferric-reducing antioxidant power (FRAP), cupric-reducing antioxidant capacity (CUPRAC) assays, and the Folin–Ciocalteu method (for the extracts). Enzyme inhibitory activities, pharmacokinetics, and drug-likeness properties of the compounds were evaluated in silico. According to the results of activity studies, the ethyl acetate subextract exhibited the highest anti-tyrosinase activity, and the remaining aqueous subextract demonstrated the highest anti-collagenase activity. The isolation studies led to the purification of euscaphic acid (1), tormentic acid (2), kaji-ichigoside F1 (3), rosamultin (4), 2-oxopomolic acid (5), and (+)-catechin (6) for the first time from the roots of this plant. Isolated compounds exhibited anti-collagenase and anti-tyrosinase activities. The extracts and (+)-catechin had higher antioxidant capacities than other compounds. R. canina roots and their compounds can be included in dermocosmetic products after further studies.
dc.identifier.doi10.1002/cbdv.202500357
dc.identifier.issn16121872
dc.identifier.pmid40512464
dc.identifier.scopus2-s2.0-105008203506
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://hdl.handle.net/11494/5608
dc.identifier.wosWOS:001507635400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorEminağaoğlu, Özgür
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofChemistry and Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCosmetic
dc.subjectIsolation
dc.subjectMolecular docking
dc.subjectRosaceae
dc.subjectSwissADME
dc.titleBioactive compounds from rosa canina l. roots with anti-collagenase, anti-tyrosinase, and antioxidant activities: In vitro and In silico approaches
dc.typeArticle

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