The effects of lycopene on hepatic ischemia/reperfusion injury in rats

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dc.authorid0000-0001-8567-807Xen_US
dc.contributor.authorBayramoğlu, Gökhan
dc.contributor.authorBayramoğlu, Ayşegül
dc.contributor.authorAltuner, Yılmaz
dc.contributor.authorUyanoğlu, Mustafa
dc.contributor.authorÇolak, Suat
dc.date.accessioned2020-11-06T07:54:24Z
dc.date.available2020-11-06T07:54:24Z
dc.date.issued2015
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.description.abstractThere is a very little information about the protective effect of lycopene (LYC) against hepatic ischemia-reperfusion injury. The present study was designed to examine the possible protective effect of the strong antioxidant and anti-inflammatory agent, LYC, on hepatic ischemia/reperfusion injury. For this purpose, rats were subjected to 45 min of hepatic ischemia followed by 60 min of reperfusion period. LYC at the doses of 2.5 and 5 mg/kg body weight (bw) were injected intraperitoneally, 60 min prior to ischemia. Upon sacrification, hepatic tissue samples were used for the measurement of catalase (CAT) activity and malondialdehyde (MDA) levels. Also, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) were assayed in serum samples. As a result of the use of LYC at the doses of 2.5 and 5 mg/kg bw; while improvements of the ALT, AST, LDH and MDA values were partial and dose-dependent, the improvement of CAT activity was total and dose-independent (p < 0.05). Our findings suggest that LYC has a protective effect against ischemia/reperfusion injury on the liver.
dc.identifier.citationBayramoğlu, G., Bayramoğlu, A., Altuner, Y., Uyanoğlu, M., & Çolak, S. (2015). The effects of lycopene on hepatic ischemia/reperfusion injury in rats. Cytotechnology, 67(3), 487-491.en_US
dc.identifier.doi10.1007/s10616-014-9706-3
dc.identifier.endpage491en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage487en_US
dc.identifier.urihttps://hdl.handle.net/11494/2418
dc.identifier.volume67en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBayramoğlu, Ayşegül
dc.institutionauthorÇolak, Suat
dc.institutionauthorBayramoğlu, Gökhan
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCytotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemia–reperfusionen_US
dc.subjectLiver Lycopeneen_US
dc.subjectOxidative stressen_US
dc.subjectRaten_US
dc.titleThe effects of lycopene on hepatic ischemia/reperfusion injury in ratsen_US
dc.typeArticle

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