The effects of hesperidin and quercetin on serum tumor necrosis factor-alpha and interleukin-6 levels in streptozotocin-induced diabetes model

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dc.authorid0000-0002-2223-1331en_US
dc.contributor.authorDokumacıoğlu, Eda
dc.contributor.authorİskender, Hatice
dc.contributor.authorŞen, Tuğba Mazlum
dc.contributor.authorİnce, İmran
dc.contributor.authorDokumacıoğlu, Ali
dc.contributor.authorKanbay, Yalçın
dc.contributor.authorErbaş, Elif
dc.contributor.authorSaral, Sinan
dc.date.accessioned2020-11-04T06:51:13Z
dc.date.available2020-11-04T06:51:13Z
dc.date.issued2018
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.description.abstractBackground: Diabetes mellitus (DM) is a metabolic disorder that occurs as a result of absolute or relative insufficiency of insulin release and/or insulin effect due to impairment of carbohydrate, fat and protein metabolism, and it is characterized by hyperglycemia and leads to various complications. Objective: In this study, it was aimed to investigate the effects of hesperidin (HP) and quercetin, which are natural flavonoids, on serum malondialdehyde (MDA), glutathione (GSH), tumor necrosis factor alpha (TNF??), and interleukin?6 (IL?6) levels in rats with streptozotocin (STZ)?induced diabetes. Materials and Methods: The experimental animals were divided into four groups, each group comprising ten rats designated as follows: Group 1 served as control rats (C); Group 2 served as diabetic rats (DM); Group 3 served as diabetic rats administered HP (DM + HP) (100 mg/kg b. w.); and Group 4 served as diabetic rats administered quercetin (DM + Q) (100 mg/kg b. w.). Results: Serum MDA and GSH levels were significantly higher in STZ?induced DM group than control group (P < 0.05). In DM + HP and DM + Q groups, MDA levels were significantly decreased compared to DM groups (P < 0.05), but there was no significant difference GSH levels between DM, DM + HP, and DM + Q groups (P > 0.05). TNF?? levels in STZ?induced DM group were significantly decreased compared to control group (P < 0.05), and groups of DM + HP and DM + Q had higher serum TNF?? levels than STZ?induced DM group (P < 0.05). In STZ?induced DM group, serum IL?6 levels were decreased compared to control group (P < 0.05). Conclusion: As a result, in this study, we determined that HP and quercetin may play an effective role in regulating insulin metabolism metabolism in diabetes. However, considering the incompatibility of various results in the literature as well as our own results, we think that the actual role of cytokines in the pathogenesis of diabetes is one of the issues that need to be clarified in further studies.
dc.description.sponsorshipThis work was supported by Coordinator of Scientific Research Projects (2015.M80.02.05) at University of Artvin Coruh.en_US
dc.identifier.citationDokumacıoğlu, E., İskender, H., Sen, T. M., İnce, I., Dokumacıoğu, A., Kanbay, Y., ... & Saral, S. (2018). The effects of hesperidin and quercetin on serum tumor necrosis factor-alpha and interleukin-6 levels in streptozotocin-induced diabetes model. Pharmacognosy magazine, 14(54), 167.en_US
dc.identifier.doi10.4103/pm.pm_41_17
dc.identifier.endpage173en_US
dc.identifier.issue54en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage167en_US
dc.identifier.urihttps://hdl.handle.net/11494/2406
dc.identifier.volume14en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorİskender, Hatice
dc.institutionauthorKanbay, Yalçın
dc.institutionauthorDokumacıoğlu, Eda
dc.language.isoenen_US
dc.publisherMedknow Publicationsen_US
dc.relation.ispartofPharmacognosy Magazine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectHesperidinen_US
dc.subjectİnterleukin‑6en_US
dc.subjectGuercetinen_US
dc.subjectTumor necrosis factor‑alphaen_US
dc.titleThe effects of hesperidin and quercetin on serum tumor necrosis factor-alpha and interleukin-6 levels in streptozotocin-induced diabetes modelen_US
dc.typeArticle

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