Lycopene partially reverses symptoms of diabetes in rats with streptozotocin-induced diabetes

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dc.authorid0000-0001-8567-807Xen_US
dc.contributor.authorBayramoğlu, Ayşegül
dc.contributor.authorBayramoğlu, Gökhan
dc.contributor.authorŞentürk, Hakan
dc.date.accessioned2020-11-10T11:14:31Z
dc.date.available2020-11-10T11:14:31Z
dc.date.issued2013
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.descriptionThis study was supported in part by the Eskisehir Osmangazi University, the Scientific Research and Application Centre (FBAM). The authors are grateful to TICAM (Medical and Surgical Experimental Research Center, Eskisehir Osmangazi University)en_US
dc.description.abstractIn the present study, we describe the effects of lycopene on the symptoms of streptozotocin (STZ)–induced diabetes in rats. Lycopene at the dose of 2.5 mg/kg body weight (bw) per day was orally administered to STZ-induced diabetic rats for a period of 7 days after onset of diabetes. At the same time, food–water intake and body weight change were recorded daily. Upon sacrifice, biochemical parameters, such as the serum glucose, insulin, total cholesterol (TC), triglyceride (TG), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), were measured in all experimental groups. Administration of lycopene at the dose of 2.5 mg/kg bw per day significantly reduced serum glucose, TC, TG, ALT, and AST levels, and increased serum insulin levels, but there were no improvements in food–water intake and body weight change parameters in lycopene-treated diabetic rats. The results suggest that orally administrated lycopene exhibits a potent hypoglycemic effect in STZ-induced diabetic rats and that lycopene may be useful for the management of diabetes mellitus.
dc.identifier.citationBayramoğlu, A., Bayramoğlu, G., & Şentürk, H. (2013). Lycopene partially reverses symptoms of diabetes in rats with streptozotocin-induced diabetes. Journal of Medicinal Food, 16(2), 128-132.en_US
dc.identifier.doi10.1089/jmf.2012.2277
dc.identifier.endpage132en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage128en_US
dc.identifier.urihttps://hdl.handle.net/11494/2438
dc.identifier.volume16en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBayramoğlu, Gökhan
dc.institutionauthorBayramoğlu, Ayşegül
dc.language.isoenen_US
dc.publisherMary Ann Liebert Inc.en_US
dc.relation.ispartofJournal of Medicinal Food
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectDiabetesen_US
dc.subjectLiveren_US
dc.subjectLycopeneen_US
dc.subjectPancreasen_US
dc.subjectRaten_US
dc.subjectStreptozotocinen_US
dc.titleLycopene partially reverses symptoms of diabetes in rats with streptozotocin-induced diabetesen_US
dc.typeArticle

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