Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome
Yükleniyor...
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer London LTD
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Abstract Background Elevated serum uric acid levels and increased arginase activity are risk factors for cardiovascular diseases (CVD). The aim of the present study was to investigate effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome (MetS). Methods Serum arginase activity, and nitrite and uric acid levels were measured in 48 women with MetS and in 20 healthy controls. The correlation of these parameters with components of MetS was also evaluated. Results Our data show statistically higher arginase activity and uric acid levels but lower nitrite levels in women with MetS compared to controls. Serum uric acid levels were negatively correlated with HDL cholesterol, nitrite levels and positively with Body Mass Index, waist to hip ratio, triglyceride and total cholesterol levels, systolic blood pressure, Homeostasis Model Assessment-Insulin Resistance-Index, serum arginase activity, and LDL-cholesterol levels in women with MetS. Conclusion Results of the present study suggest that serum uric acid levels may contribute to the pathogenesis of MetS through a process mediated by arginase pathway, and serum arginase activity and nitrite and uric acid levels can be used as indicators of CVD in women with MetS.
Açıklama
Anahtar Kelimeler
Arginase pathway, Metabolic syndrome, Serum uric acid levels
Kaynak
Irish Journal of Medical Science.
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
185
Sayı
1
Künye
Uslu, S., Özçelik, E., Kebapçı, N., Temel, H. E., Demirci, F., Ergün, B., & Demirüstü, C. (2016). Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome. Irish Journal of Medical Science. 185(1), 259-263.
