Determination of the relationship between rs4986790 and rs4986791 variants of TLR4 gene and lung cancer
Yükleniyor...
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer New York LLC
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Chronic inflammation triggers DNA damage and oncogenic mutations and causes tumor formation and tumor progression. One of the important components of the inflammatory response is Toll-like receptor (TLR) family. The objective of our study is to determine the relationship between rs4986790(+896A/G) and rs4986791(+1196C/T) gene polymorphisms and lung cancer risk. PCR-RFLP technique was carried out to identify the genotypes in 100 control individuals and 160 lung cancer patients. DNA extracted from peripheral blood samples were amplified and digested with NcoI and HinfI then visualized. We did not find any difference between genotype frequencies between controls and patients (p > 0.05) in rs4986790. But a significant difference between control group and patients with lung cancer as for genotype frequencies (? (2) = 4.19, p = 0.041) in rs4986791 variants was found. Our data indicate that any correlation was not found between rs4986790 polymorphism and lung cancer, while a correlation between rs4986791 and lung cancer has been determined and found to be associated with lung cancer risk.
Açıklama
Eskisehir Osmangazi University: 201311D08
Anahtar Kelimeler
Lung cancer, Polymorphism, rs4986790, rs4986791, Toll-like receptor-4
Kaynak
Inflammation
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
39
Sayı
1
Künye
Kurt, H., Özbayer, C., Bayramoğlu, A., Güneş, H. V., Değirmenci, İ., Öner, K. S., & Metintaş, M. (2016). Determination of the relationship between rs4986790 and rs4986791 variants of TLR4 gene and lung cancer. Inflammation, 39(1), 166-171.
