Determination of the relationship between rs4986790 and rs4986791 variants of TLR4 gene and lung cancer

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dc.authorid0000-0002-1120-1874en_US
dc.authorid0000-0001-8567-807Xen_US
dc.contributor.authorHülyam, Kurt
dc.contributor.authorÖzbayer, Cansu
dc.contributor.authorBayramoğlu, Ayşegül
dc.contributor.authorGüneş, Hasan Veysi
dc.contributor.authorDegirmenci, İrfan
dc.contributor.authorÖner, Kevser Setenay
dc.contributor.authorMetintaş, Muzaffer
dc.date.accessioned2020-11-06T10:24:33Z
dc.date.available2020-11-06T10:24:33Z
dc.date.issued2016
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.descriptionEskisehir Osmangazi University: 201311D08en_US
dc.description.abstractChronic inflammation triggers DNA damage and oncogenic mutations and causes tumor formation and tumor progression. One of the important components of the inflammatory response is Toll-like receptor (TLR) family. The objective of our study is to determine the relationship between rs4986790(+896A/G) and rs4986791(+1196C/T) gene polymorphisms and lung cancer risk. PCR-RFLP technique was carried out to identify the genotypes in 100 control individuals and 160 lung cancer patients. DNA extracted from peripheral blood samples were amplified and digested with NcoI and HinfI then visualized. We did not find any difference between genotype frequencies between controls and patients (p > 0.05) in rs4986790. But a significant difference between control group and patients with lung cancer as for genotype frequencies (? (2) = 4.19, p = 0.041) in rs4986791 variants was found. Our data indicate that any correlation was not found between rs4986790 polymorphism and lung cancer, while a correlation between rs4986791 and lung cancer has been determined and found to be associated with lung cancer risk.
dc.identifier.citationKurt, H., Özbayer, C., Bayramoğlu, A., Güneş, H. V., Değirmenci, İ., Öner, K. S., & Metintaş, M. (2016). Determination of the relationship between rs4986790 and rs4986791 variants of TLR4 gene and lung cancer. Inflammation, 39(1), 166-171.en_US
dc.identifier.doi10.1007/s10753-015-0235-9
dc.identifier.endpage171en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage166en_US
dc.identifier.urihttps://hdl.handle.net/11494/2421
dc.identifier.volume39en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBayramoğlu, Ayşegül
dc.language.isoenen_US
dc.publisherSpringer New York LLCen_US
dc.relation.ispartofInflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLung canceren_US
dc.subjectPolymorphismen_US
dc.subjectrs4986790en_US
dc.subjectrs4986791en_US
dc.subjectToll-like receptor-4en_US
dc.titleDetermination of the relationship between rs4986790 and rs4986791 variants of TLR4 gene and lung canceren_US
dc.typeArticle

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