Secondary sulfonamides as effective lactoperoxidase inhibitors
Yükleniyor...
Dosyalar
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
MDPI
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Secondary sulfonamides (4a–8h) incorporating acetoxybenzamide, triacetoxybenzamide, hydroxybenzamide, and trihydroxybenzamide and possessing thiazole, pyrimidine, pyridine, isoxazole and thiadiazole groups were synthesized. Lactoperoxidase (LPO, E.C.1.11.1.7), as a natural antibacterial agent, is a peroxidase enzyme secreted from salivary, mammary, and other mucosal glands. In the present study, the in vitro inhibitory effects of some secondary sulfonamide derivatives (4a–8h) were examined against LPO. The obtained results reveal that secondary sulfonamide derivatives (4a–8h) are effective LPO inhibitors. The Ki values of secondary sulfonamide derivatives (4a–8h) were found in the range of 1.096 × 10?3 to 1203.83 µM against LPO. However, the most effective inhibition was found for N-(sulfathiazole)-3,4,5-triacetoxybenzamide (6a), with Ki values of 1.096 × 10?3 ± 0.471 × 10?3 µM as non-competitive inhibition.
Açıklama
Anahtar Kelimeler
Lactoperoxidase, Secondary sulfonamide, Enzyme purification, Enzyme inhibition
Kaynak
Molecules
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
22
Sayı
6
Künye
Köksal, Z., Kalın, R., Camadan, Y., Usanmaz, H., Almaz, Z., Gülçin, I., ... & Özdemir, H. (2017). Secondary sulfonamides as effective lactoperoxidase inhibitors. Molecules, 22(6), 793. Doi: 10.3390/molecules22060793
