Secondary sulfonamides as effective lactoperoxidase inhibitors

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dc.authorid0000-0002-5470-130Xen_US
dc.authorid0000-0001-5993-1668en_US
dc.authorid0000-0002-4532-4311en_US
dc.authorid0000-0001-8203-4623en_US
dc.contributor.authorKöksal, Zeynep
dc.contributor.authorKalın, Ramazan
dc.contributor.authorCamadan, Yasemin
dc.contributor.authorUsanmaz, Hande
dc.contributor.authorAlmaz, Züleyha
dc.contributor.authorGülçin, İlhami
dc.contributor.authorĞökçe, Taner
dc.contributor.authorGören, Ahmet Ceyhan
dc.contributor.authorÖzdemir, Hasan
dc.date.accessioned2020-10-28T08:02:24Z
dc.date.available2020-10-28T08:02:24Z
dc.date.issued2017
dc.departmentAÇÜ, Sağlık Hizmetlerien_US
dc.description.abstractSecondary sulfonamides (4a–8h) incorporating acetoxybenzamide, triacetoxybenzamide, hydroxybenzamide, and trihydroxybenzamide and possessing thiazole, pyrimidine, pyridine, isoxazole and thiadiazole groups were synthesized. Lactoperoxidase (LPO, E.C.1.11.1.7), as a natural antibacterial agent, is a peroxidase enzyme secreted from salivary, mammary, and other mucosal glands. In the present study, the in vitro inhibitory effects of some secondary sulfonamide derivatives (4a–8h) were examined against LPO. The obtained results reveal that secondary sulfonamide derivatives (4a–8h) are effective LPO inhibitors. The Ki values of secondary sulfonamide derivatives (4a–8h) were found in the range of 1.096 × 10?3 to 1203.83 µM against LPO. However, the most effective inhibition was found for N-(sulfathiazole)-3,4,5-triacetoxybenzamide (6a), with Ki values of 1.096 × 10?3 ± 0.471 × 10?3 µM as non-competitive inhibition.
dc.identifier.citationKöksal, Z., Kalın, R., Camadan, Y., Usanmaz, H., Almaz, Z., Gülçin, I., ... & Özdemir, H. (2017). Secondary sulfonamides as effective lactoperoxidase inhibitors. Molecules, 22(6), 793. Doi: 10.3390/molecules22060793en_US
dc.identifier.doi10.3390/molecules22060793
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/11494/2391
dc.identifier.volume22en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorCamadan, Yasemin
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofMolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLactoperoxidaseen_US
dc.subjectSecondary sulfonamideen_US
dc.subjectEnzyme purificationen_US
dc.subjectEnzyme inhibitionen_US
dc.titleSecondary sulfonamides as effective lactoperoxidase inhibitorsen_US
dc.typeArticle

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