Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives
Yükleniyor...
Dosyalar
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The Naturally occurring novel cyclohexanonyl bromophenol 2(R)-2-(2,3,6-tribromo-4,5-dihydroxybenzyl)cyclohexanone (4) was synthesized as a racemic compound. Cyclohexylphenyl methane derivatives (10–17) with Br, OMe, CO, and OH were also obtained. Inhibition of four human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I, II, IV, and VI, with compounds 2–4, 8, and 10–26 was investigated. These compounds were found to be promising carbonic anhydrase inhibitors and some of them showed interesting inhibitory activity. Some of the compounds investigated here showed effective hCA inhibitory activity, and might be used as leads for generating novel carbonic anhydrase inhibitors which are valuable drug candidates for the treatment of glaucoma, epilepsy, gastric and duodenal ulcers, neurological disorders, and osteoporosis.
Açıklama
Anahtar Kelimeler
Carbonic anhydrase, Enzyme inhibition, Bromination, Bromophenols, Cyclohexanone with benzyl, Enamine, Esterification, Symphyoketone
Kaynak
Bioorganic & Medicinal Chemistry Letters
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
22
Sayı
3
Künye
Balaydın, H. T., Şentürk, M., & Menzek, A. (2012). Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives. Bioorganic & Medicinal Chemistry Letters, 22(3), 1352-1357.
