Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives

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dc.authorid0000-0001-5968-7511en_US
dc.contributor.authorBalaydın, Halis Türker
dc.contributor.authorŞentürk, Murat
dc.contributor.authorMenzek, Abdullah
dc.date.accessioned2020-11-09T12:48:10Z
dc.date.available2020-11-09T12:48:10Z
dc.date.issued2012
dc.departmentAÇÜ, Eğitim Fakültesien_US
dc.description.abstractThe Naturally occurring novel cyclohexanonyl bromophenol 2(R)-2-(2,3,6-tribromo-4,5-dihydroxybenzyl)cyclohexanone (4) was synthesized as a racemic compound. Cyclohexylphenyl methane derivatives (10–17) with Br, OMe, CO, and OH were also obtained. Inhibition of four human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I, II, IV, and VI, with compounds 2–4, 8, and 10–26 was investigated. These compounds were found to be promising carbonic anhydrase inhibitors and some of them showed interesting inhibitory activity. Some of the compounds investigated here showed effective hCA inhibitory activity, and might be used as leads for generating novel carbonic anhydrase inhibitors which are valuable drug candidates for the treatment of glaucoma, epilepsy, gastric and duodenal ulcers, neurological disorders, and osteoporosis.
dc.description.sponsorshipTurkiye Cumhuriyeti Kalkinma Bakanligi: 2010K120440 Artvin Coruh University: 2011-F30.02.21en_US
dc.identifier.citationBalaydın, H. T., Şentürk, M., & Menzek, A. (2012). Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives. Bioorganic & Medicinal Chemistry Letters, 22(3), 1352-1357.en_US
dc.identifier.doi10.1016/j.bmcl.2011.12.069
dc.identifier.endpage1357en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage1352en_US
dc.identifier.urihttps://hdl.handle.net/11494/2434
dc.identifier.volume22en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBalaydın, Halis Türker
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofBioorganic & Medicinal Chemistry Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectBrominationen_US
dc.subjectBromophenolsen_US
dc.subjectCyclohexanone with benzylen_US
dc.subjectEnamineen_US
dc.subjectEsterificationen_US
dc.subjectSymphyoketoneen_US
dc.titleSynthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivativesen_US
dc.typeArticle

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