Anticancer potential of bellardia trixago quantum dots: Cytotoxic effects on various cancer cell lines

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dc.contributor.authorAytar, Erdi Can
dc.contributor.authorSarı, Zeynep Betul
dc.contributor.authorSarı, Muhammet Emin
dc.contributor.authorDurmaz, Alper
dc.contributor.authorİncilay Torunoğlu, Emine
dc.contributor.authorGümrükçüoğlu, Abidin
dc.date.accessioned2025-06-22T12:54:09Z
dc.date.available2025-06-22T12:54:09Z
dc.date.issued2025
dc.departmentAÇÜ
dc.description.abstractThis study investigates the synthesis, characterization, and anticancer effects of carbon quantum dots (CQDs) derived from Bellardia trixago. The CQDs were analyzed using Transmission Electron Microscopy (TEM), X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and X-ray Photoelectron Spectroscopy (XPS). TEM results revealed that the CQDs have a spherical morphology and exhibit a layered structure. XRD analysis showed a graphite-like crystalline structure, while FTIR and XPS studies confirmed the presence of OH, C[dbnd]C, and C[sbnd]O functional groups on the surface. The biological activity of CQDs demonstrated selective cytotoxicity, inducing significant cell death in cancer cells while exhibiting low toxicity in healthy cells. More pronounced morphological changes were observed in HEp-2 and SaOS-2 cells, while HEK-293 cells showed negligible changes. These findings suggest that quantum dots could serve as a potential alternative for cancer treatment.
dc.identifier.doi10.1016/j.bioorg.2025.108340
dc.identifier.issn00452068
dc.identifier.pmid40073593
dc.identifier.scopus2-s2.0-86000591313
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/11494/5575
dc.identifier.volume158
dc.identifier.wosWOS:001445244800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorDurmaz, Alper
dc.institutionauthorGümrükçüoğlu, Abidin
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.relation.ispartofBioorganic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBellardia trixago
dc.subjectCarbon quantum dots
dc.subjectCytotoxicity
dc.subjectFourier transform infrared spectroscopy
dc.subjectTransmission Electron microscopy
dc.subjectX-ray diffraction
dc.subjectX-ray photoelectron spectroscopy
dc.titleAnticancer potential of bellardia trixago quantum dots: Cytotoxic effects on various cancer cell lines
dc.typeArticle

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