The effect of hesperidin and quercetin on oxidative stress, NF-kappa B and SIRT1 levels in a STZ-induced experimental diabetes model
Yükleniyor...
Dosyalar
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier France-Editions Scientifiques Medicales Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The aim of this study is to investigate the roles of SIRT1 and NF-kB in the pathogenesis of diabetes mellitus in rats with STZ-induced diabetes and determine the effects of hesperidin and quercetin on oxidative stress and on the levels of SIRT1 and NF-kB. Materials and methods: The experimental animals were divided into four groups, each group comprising ten rats designated as follows: group 1 served as control rats (C); group 2 served as diabetic rats (DM); group 3 served as diabetic rats administered hesperidin (DM + HSP) (100 mg/kg b.w.) in aqueous suspension orally for 15 days; and group 4 served as diabetic rats administered quercetin (DM + Q) (100 mg/kg b.w.) in aqueous suspension orally for 15 days. Results: In diabetic group, liver and kidney SIRT1, SOD and CAT activities were significantly lower than control group (p < 0.05). Hesperidin and quercetin caused significant increase in the SIRT1, SOD and CAT activities of both DM + HP and DM + Q groups kidney tissues compared to DM group (p < 0.05). Liver SOD activies were not found to differ significantly between DM, DM + Q and DM + HP groups (p > 0.05). In DM + HP group, liver CAT activities were significantly higher than DM (p < 0.05), but there was no significant difference in liver CAT activities between DM and DM + Q (p > 0.05). In diabetic group, liver and kidney NF-kB and MDA levels were increased compared to control group (p < 0.05), and groups of DM + HP and DM + Q had lower NF-kB and MDA levels than diabetic group (p < 0.05). Conclusion: As a conclusion, based on the results we obtained from this study and the literature data discussed above, we determined in STZ-induced diabetic rats that, increased glucose levels and liver and kidney damage markers decreased significantly after administration of hesperedin and quercetin, and that oxidative stress and NF-kB levels increased while SIRT1 levels decreased in the diabetic group
Açıklama
Anahtar Kelimeler
Diabetes, Hesperidin, NF-kB, Oxidative stress, Quercetin, Sirtuin
Kaynak
Biomedicine and Pharmacotherapy
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
90
Sayı
Künye
Iskender, H., Dokumacıoğlu, E., Şen, T. M., İnce, I., Kanbay, Y., & Saral, S. (2017). The effect of hesperidin and quercetin on oxidative stress, NF-κB and SIRT1 levels in a STZ-induced experimental diabetes model. Biomedicine & Pharmacotherapy, 90, 500-508. Doi: 10.1016/j.biopha.2017.03.102
