The effect of hesperidin and quercetin on oxidative stress, NF-kappa B and SIRT1 levels in a STZ-induced experimental diabetes model

Basit Öğe Kaydı
dc.authorid0000-0002-2223-1331en_US
dc.authorid0000-0003-2680-5205en_US
dc.contributor.authorİskender, Hatice
dc.contributor.authorDokumacıoğlu, Eda
dc.contributor.authorŞen, Tuğba Mazlum
dc.contributor.authorİnce, İmran
dc.contributor.authorKanbay, Yalçın
dc.contributor.authorSaral, Sinan
dc.date.accessioned2020-10-28T05:51:46Z
dc.date.available2020-10-28T05:51:46Z
dc.date.issued2017
dc.departmentAÇÜ, Sağlık Bilimleri Fakültesien_US
dc.description.abstractObjective: The aim of this study is to investigate the roles of SIRT1 and NF-kB in the pathogenesis of diabetes mellitus in rats with STZ-induced diabetes and determine the effects of hesperidin and quercetin on oxidative stress and on the levels of SIRT1 and NF-kB. Materials and methods: The experimental animals were divided into four groups, each group comprising ten rats designated as follows: group 1 served as control rats (C); group 2 served as diabetic rats (DM); group 3 served as diabetic rats administered hesperidin (DM + HSP) (100 mg/kg b.w.) in aqueous suspension orally for 15 days; and group 4 served as diabetic rats administered quercetin (DM + Q) (100 mg/kg b.w.) in aqueous suspension orally for 15 days. Results: In diabetic group, liver and kidney SIRT1, SOD and CAT activities were significantly lower than control group (p < 0.05). Hesperidin and quercetin caused significant increase in the SIRT1, SOD and CAT activities of both DM + HP and DM + Q groups kidney tissues compared to DM group (p < 0.05). Liver SOD activies were not found to differ significantly between DM, DM + Q and DM + HP groups (p > 0.05). In DM + HP group, liver CAT activities were significantly higher than DM (p < 0.05), but there was no significant difference in liver CAT activities between DM and DM + Q (p > 0.05). In diabetic group, liver and kidney NF-kB and MDA levels were increased compared to control group (p < 0.05), and groups of DM + HP and DM + Q had lower NF-kB and MDA levels than diabetic group (p < 0.05). Conclusion: As a conclusion, based on the results we obtained from this study and the literature data discussed above, we determined in STZ-induced diabetic rats that, increased glucose levels and liver and kidney damage markers decreased significantly after administration of hesperedin and quercetin, and that oxidative stress and NF-kB levels increased while SIRT1 levels decreased in the diabetic group
dc.description.sponsorshipFunding Agency: Coordinator of Scientific Research Projects at University of Artvin Coruh, Grant Number: 2015.M80.02.05.en_US
dc.identifier.citationIskender, H., Dokumacıoğlu, E., Şen, T. M., İnce, I., Kanbay, Y., & Saral, S. (2017). The effect of hesperidin and quercetin on oxidative stress, NF-κB and SIRT1 levels in a STZ-induced experimental diabetes model. Biomedicine & Pharmacotherapy, 90, 500-508. Doi: 10.1016/j.biopha.2017.03.102en_US
dc.identifier.doi10.1016/j.biopha.2017.03.102
dc.identifier.endpage508en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage500en_US
dc.identifier.urihttps://hdl.handle.net/11494/2389
dc.identifier.volume90en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDokumacıoğlu, Eda
dc.institutionauthorKanbay, Yalçın
dc.institutionauthorİskender, Hatice
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofBiomedicine and Pharmacotherapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectHesperidinen_US
dc.subjectNF-kBen_US
dc.subjectOxidative stressen_US
dc.subjectQuercetinen_US
dc.subjectSirtuinen_US
dc.titleThe effect of hesperidin and quercetin on oxidative stress, NF-kappa B and SIRT1 levels in a STZ-induced experimental diabetes modelen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
hatice.iskender.pdf
Boyut:
868.88 KB
Biçim:
Adobe Portable Document Format
Açıklama:
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Beslenme ve Diyetetik Bölümü Yayın Koleksiyonu
Hemşirelik Bölümü Yayın Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu