Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats
Yükleniyor...
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
There is little information about the hepatoprotective effects of gallic acid against ischemia-reperfusion (I/R) damage. Animals were subjected to I/R. Gallic acid at doses of 50 and 100 mg/kg body weight (bw) were injected as a single dose prior to ischemia. Liver tissue homogenates were used for the measurement of malondialdehyde (MDA), catalase (CAT) and glutathione peroxidase (GPx) levels. At the same time alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were assayed in serum samples and compared statistically. While the ALT, AST, LDH activities and MDA levels were significantly increased, CAT and GPx activities significantly decreased in only I/R-induced control rats compared to normal control rats (P < 0.05). Treatment with gallic acid at a dose of 100 mg/kg bw significantly decreased the ALT, AST, LDH activities and MDA levels, and markedly increased activities of CAT and GPx in tissue homogenates compared to I/R-induced rats with no treatment group (P < 0.05). In oxidative stress generated by hepatic ischemia-reperfusion, gallic acid contributes partially an alteration in the delicate balance between the scavenging capacity of antioxidant defense systems and free radicals in favour of the antioxidant defense systems in the body.
Açıklama
Anahtar Kelimeler
Gallic acid, Ischemia–reperfusion, Liver, Oxidative stress, Rat
Kaynak
Cytotechnology
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
67
Sayı
5
Künye
Bayramoğlu, G., Kurt, H., Bayramoğlu, A., Güneş, H. V., Değirmenci, I., & Colak, S. (2015). Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats. Cytotechnology, 67(5), 845-849.
