Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats

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dc.authorid0000-0001-8567-807Xen_US
dc.contributor.authorBayramoğlu, Gökhan
dc.contributor.authorKurt, Hülyam
dc.contributor.authorBayramoğlu, Ayşegül
dc.contributor.authorGüneş, Hasan Veysi
dc.contributor.authorDeğirmenci, İrfan
dc.contributor.authorÇolak, Suat
dc.date.accessioned2020-11-12T07:45:23Z
dc.date.available2020-11-12T07:45:23Z
dc.date.issued2015
dc.departmentAÇÜ, Artvin Meslek Yüksekokuluen_US
dc.description.abstractThere is little information about the hepatoprotective effects of gallic acid against ischemia-reperfusion (I/R) damage. Animals were subjected to I/R. Gallic acid at doses of 50 and 100 mg/kg body weight (bw) were injected as a single dose prior to ischemia. Liver tissue homogenates were used for the measurement of malondialdehyde (MDA), catalase (CAT) and glutathione peroxidase (GPx) levels. At the same time alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were assayed in serum samples and compared statistically. While the ALT, AST, LDH activities and MDA levels were significantly increased, CAT and GPx activities significantly decreased in only I/R-induced control rats compared to normal control rats (P < 0.05). Treatment with gallic acid at a dose of 100 mg/kg bw significantly decreased the ALT, AST, LDH activities and MDA levels, and markedly increased activities of CAT and GPx in tissue homogenates compared to I/R-induced rats with no treatment group (P < 0.05). In oxidative stress generated by hepatic ischemia-reperfusion, gallic acid contributes partially an alteration in the delicate balance between the scavenging capacity of antioxidant defense systems and free radicals in favour of the antioxidant defense systems in the body.
dc.identifier.citationBayramoğlu, G., Kurt, H., Bayramoğlu, A., Güneş, H. V., Değirmenci, I., & Colak, S. (2015). Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats. Cytotechnology, 67(5), 845-849.en_US
dc.identifier.doi10.1007/s10616-014-9724-1
dc.identifier.endpage849en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage845en_US
dc.identifier.urihttps://hdl.handle.net/11494/2443
dc.identifier.volume67en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBayramoğlu, Ayşegül
dc.institutionauthorÇolak, Suat
dc.institutionauthorBayramoğlu, Gökhan
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCytotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGallic aciden_US
dc.subjectIschemia–reperfusionen_US
dc.subjectLiveren_US
dc.subjectOxidative stressen_US
dc.subjectRaten_US
dc.titlePreventive role of gallic acid on hepatic ischemia and reperfusion injury in ratsen_US
dc.typeArticle

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